Doxycycline hyclate belongs to the group of tetracyclines antibiotics and the sphere of its application is extremely wide. This medicine is distinguished by quick action and practically doesn’t harm the organism. Doxycycline Hyclate and its indications became very famous recently. The point is that many doctors define this antibiotic as outdated and inefficient, but at the same time American scientists consider it reasonable to use this remedy for treatment of 90% of various infectious diseases.
People around the world have been using this antibiotic since 50 years therefore there are assumptions that microorganisms have got resistant to this Antibiotics. Nevertheless doctors still continue to prescribe it to the patients as the potential threat to health from this drug is minimal, and the ability to counteract various infections is very high.
100 mg of the drug is well absorbed in the digestive tract (more than 90%) and quickly reach therapeutic concentration in blood plasma; meal doesn’t infleunce the absorption. About 90% of the remedy contact proteins of blood. About 50% of the dose taken is removed with urine, the insignificant amount of the remedy is excreted with bile. Therapeutic concentration in blood is detected 10 min after oral intake. Doxycycline accumulates in pleural liquid, a small amount of it gets into cerebrospinal fluid. In comparison with other medicines of the tetracyclines group, the intake of the drug causes development of side effects less often. Its elimination half-life makes 18,5–22,2 h both in persons with normal, and with impaired kidneys function. Hemodialysis doesn’t influence the speed of elimination of the antibiotic. Owing to the prolonged action it’s enough to take doxycycline 1 time a day.
The active ingredient successfully gets practically into all tissues and organs of the organism, only the hematoencephalic barrier can be an obstacle. This medicine can be found in insignificant quantity or is not detected at all if there are intact brain tunics in cerebrospinal fluid. Its presence in breast milk , as well as in the organism of the fetus has been proven as the substance gets through the placenta barrier. Distribution comes at a rate of 0,7 l per each kilogram of the body weight. About 30-60% is removed by the liver, the elimination half-life of the drug takes 16 hours on average. The probability of its accumulation increases at repeated reception. The medicine promotes accumulation of insoluable complexes with Ca2+ in teeth and bones.
Because of safety of the medicine the dose correction at elderly patients doesn’t occur, as well as at kidney disfunction as an excessive accumulation of the active ingredient in kidneys doesn’t happen. Liver failure in turn is a reason for dose correction or more careful drug intake.
