What is Doxycycline Hyclate?

By Robert Martinez
Updated 2024-04-10 04:31:54 | Published 2018-10-08 19:05:43
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Doxycycline Hyclate

Uses of Doxycycline Hyclate

Doxycycline Hyclate is an antibiotic primarily used to treat diseases caused by intracellular pathogenic microorganisms such as chlamydia and mycoplasma. It is also employed in the treatment of black fever, typhus, borreliosis, brucellosis, yersiniosis, bacillar and amoebic dysentery, tularemia, cholera, actinomycosis, malaria, leptospirosis, trachoma, ornithosis, granulocytic ehrlichiosis, and other infections of the nasopharynx and lower respiratory tract.

Preventive Measures

This medication is also used for the prevention of surgical infections following medical abortions and colon operations, as well as for the prevention of malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) in regions where the plasmodium may be resistant to chloroquine and/or pyrimethamine-sulphadoxine.

Consultation and Contraindications

Before using Doxycycline Hyclate, it is crucial to consult a doctor. There are certain contraindications associated with its use, including hypersensitivity, porphyria, severe liver failure, leukopenia, pregnancy (second half), breastfeeding (discontinue breastfeeding during treatment), and children under 9 years old (during tooth development).

Side Effects of Doxycycline Hyclate

Potential side effects of Doxycycline Hyclate include dizziness, sweating, vascular collapse, benign intracranial hypertension in adults and fontanel bulge in children, nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, dysbacteriosis, fungal infections, reinfection by resistant strains, eosinophilia, neutropenia, photosensitivity, permanent tooth enamel discoloration, and allergic reactions (rash, itching, Quincke's edema).

Drug Interactions

Doxycycline Hyclate's effectiveness may be reduced when taken simultaneously with iron, sodium bicarbonate, aluminum, calcium or magnesium antacids, magnesium-containing relaxants, cholestyramine, and colestipol. Barbiturates, carbamazepine, phenytoin, and rifampicin can decrease the drug's plasma concentration and elimination half-life, potentially diminishing its antimicrobial effect. Doxycycline Hyclate may also reduce the bactericidal effect of penicillin and the reliability of contraception.

Special Instructions for Use

Treatment of infections caused by streptococcus, staphylococcus, Escherichia, Shigella, and Acinetobacter should only be initiated after determining the microorganism's sensitivity to Doxycycline. To prevent esophageal ulceration, take the medication with a large amount of liquid. During treatment and within 4-5 days after direct sun or UV exposure, avoid sunlight (due to photosensitivity). For prolonged use, monitor peripheral blood cell composition, perform liver function tests, and check serum nitrogen and urea levels. Be aware that sulfites contained in the medication may cause allergic reactions, ranging from anaphylaxis to severe asthma attacks.

By understanding the uses, contraindications, side effects, and interactions associated with Doxycycline Hyclate, patients can make informed decisions about their treatment and enjoy a safer, more effective recovery from various infections.

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