What is Doxycycline Hyclate?

Doxycycline hyclate is intended for treatment of the diseases caused by intracellular pathogenic microorganisms (chlamydias, mycoplasmas); also black fever, typhus, borreliosis, brucellosis, yersiniosis, bacillar and amoebic dysentery, tularemia, cholera, actinomycosis, Malaria, leptospirosis, trachoma, ornithosis, granulocytic ehrlichiosis, etc.; diseases of nasopharynx and lower parts of airways.

This medicine is used also for prevention of surgical infections after medical abortions, colon operations, prevention of malaria caused by Plasmodium falciparum during short-term journeys (less than 4 months) in the territory where the plasmodium can be resistant to chloroquine and/or pyrimethamine- sulphadoxine.

Consult the doctor before using this substance.

There are certain contraindications concerning use of this medicine:

  • hypersensitivity
  • porfiriya
  • heavy liver failure
  • leykopenia
  • pregnancy (second half)
  • breast feeding (for the period of treatment refuse breast feeding)

Doxycycline hyclate is also contraindicated for children up to 9 years (in the period of teeth development).

As for side effects, following symptoms can be observed: dizziness, perspiration, vascular collapse, benign intracranial hypertension at adults and fontanel bulge at children, nausea, vomiting, anorexia, abdominalgia, diarrhea, coprostasia, dysphagy, glossit, esophagitis, dysbacteriosis, fungal infections, reinfection by resistant strains, eosinophilia, neutropenia, photosensitizing, steady change of tooth enamel color, allergic reactions (rash, itch, Quincke's edema).

Doxycycline hyclate is less effective in case of simultaneous intake with drugs of iron, sodium hydrocarbonate, aluminum, calcic or magnesian antatsids, magnesium-containing relaxants, cholestyramine and colestipol. Barbiturates, carbamazepine, phenytoin, rifampicin reduce concentration of the drug in plasma and reduce its elimination half-life that can decrease its antimicrobic effect. This medicine also reduces bactericidal effect of penicillin and reliability of contraception.

Special instructions

Treatment of the infections caused by strepto- and staphylococcus, escherichias, shigellas, acinetobacters is possible only after determination of microorganism sensitivity to doxycycline. For prevention of esophagus ulceration take the medicine with large amount of liquid. During treatment and within 4-5 days after direct radiation by sunlight or UF beams it is contraindicated (because of photosensitizing). At prolonged use control peripheral blood cell composition, make functional hepatic tests, monitor nitrogen and urea level in serum. Sulfites contained in the medicine can cause allergic reactions up to anaphylaxis and heavy attacks of bronchial asthma.

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