Over time, many medications may lose their initial efficacy, and Cialis is no exception. The active ingredient in Cialis, Tadalafil, belongs to the class of PDE-5 inhibitors. While endocrinopathy and diabetic neuropathy are the primary causes of initial resistance to PDE-5 inhibitors, drug resistance may also develop and intensify with prolonged use.

Reduced susceptibility to Tadalafil often leads patients to increase their dosage, which in turn raises the risk of adverse effects. In this article, we will explore the main causes of drug resistance and discuss potential solutions.

Venous insufficiency

Cialis may not be effective if erectile dysfunction is associated with venous insufficiency of the penis. This condition is characterized by an increased venous blood outflow from the cavernous bodies of the penis, despite normal arterial inflow. The underlying causes may include:

  • Smooth muscle dysfunction
  • Structural problems in the erectile tissue (reduced elasticity of the cavernous bodies)
  • Traumatic effects

In many cases, venous insufficiency is linked to reduced testosterone levels. Therefore, restoring testosterone levels may help alleviate this issue.

Low nitric oxide levels

Nitric oxide plays a crucial role in achieving an erection by dilating blood vessels and promoting blood flow to the penis. Cialis and similar drugs do not directly increase nitric oxide levels but instead inhibit the enzyme responsible for its decomposition. However, the natural production of nitric oxide decreases by approximately 50% in men over the age of 40.

To address this issue, men can consider modifying their diet to include nitric oxide-rich foods such as spinach and beet juice or take biologically active dietary supplements containing this chemical compound.

Psychological problems

In some cases, erectile dysfunction may stem from psychological factors rather than physiological ones. Fears, anxiety, stress, and other emotional issues can prevent a man from achieving an erection, even if his body is otherwise healthy. This condition, known as psychogenic erectile dysfunction, typically requires comprehensive medical intervention. In such cases, Cialis may serve as a complementary treatment to other therapies.

Other medical issues

The effectiveness of Cialis may be reduced in individuals with certain health conditions, including:

  • Prostatitis
  • Pelvic surgery
  • Back injuries
  • Major cardiovascular disorders

If Cialis does not seem to be working as expected, it is essential to consult a healthcare professional. Only a specialist can provide the necessary guidance and help determine the most appropriate course of action to address the underlying issues and optimize treatment outcomes.

Drugs|Erectile Dysfunction|Men’s Health