Januvia (Sitagliptin Phosphate)

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Januvia (Sitagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.
Active Ingredient: Sitagliptin Phosphate
Dosage Form: Tablet
Dosage: 100 mg Tablet;
Minimum Market Price: $3.99

General Information

The pandemic of diabetes embraced the whole world. This insidious disease ruthlessly sucks the health of the entire population. According to preliminary data, this health disorder takes the third place among the main causes of people’s mortality. Basing on these data diabetes is taken under strict state control in many countries.

The world medical database possesses information that it is quite possible to control this pathology. Many treatment regimens have shown an excellent result in this disease progress termination as well as in reducing side effects caused by this disorder.

Unfortunately, no one has been able to cure diabetes, but there is a special, effective strategy for managing patients with this pathology:

  1. The correct way of life is a technique which has proved itself at the highest level. A special diet in combination with a complex of physical activities and the normalization of the psycho-emotional state gives a perfect result.
  2. Medicament therapy – oral hypoglycemic medications, insulin therapy and incretinomimetics, these are the measures without which it is impossible to ensure the normal life of this category of health-care consumer.

The main goal of type 2 diabetes therapy is strict control of carbohydrate, lipid metabolism and blood pressure indicators including the establishment of a healthy lifestyle.

The Generic Januvia (Sitagliptin Phosphate) is an antidiabetic medication, which is intended for non-insulin dependent diabetes treatment. The main substance of the remedy is Sitagliptin, which has a direct influence on the amount of glucose and pancreatic hormone in the body.

Sitagliptin has a significantly different composition and exposure comparing to other substances which are considered to be its analogues, such as enteroglucagon, albuminous hormone of the pancreas, insulin, synthetic antidiabetics, hypoglycemic drugs, thiazolidinediones, alpha-glucosidase inhibitors, islet amyloid polypeptide of the pancreatic gland.

This substance, which is a DPP-IV inhibitor, increases the amount of such vital enzymes as enteroglucagon and gastroinhibitory polypeptide. The amount of enzymes rises after eating, which leads to normal assimilation and dextrose level regulation.

The agent is prescribed to those who are diagnosed with non-insulin-dependent diabetes. Good results are seen immediately after it is taken for the first time. Madicine is applied either as a monotherapy or in a complex treatment. The remedy is prescribed for non-insulin-dependent diabetes, especially in cases when recommended diet and sports exercise restrictions do not give the desired result. Usage of this medication reduces the risk of a significant decrease in serum glucose.


The must be avoided if any of the following factors is present:

  • insulin-dependent diabetes (pancreatic diabetes of type 1)
  • bearing a child
  • breastfeeding
  • metabolic acidosis, tied to a carbohydrate metabolism disorder, which arose due to insulin deficiency
  • increased susceptibility to the substances which are the part of the remedy
  • children and teenagers under 18 years.

There is no information or research on the medicine impact on the fetus in the womb of a woman, so it is better to cancel taking the product in pregnancy. Treatment with this remedy should abandon breastfeeding, as there is also no information about the main substance of the remedy penetration into the breast milk.


The daily amount of this medicine equals to 100 mg and is taken once a day per os, independently the food intake, either including other antihyperglycaemic agents or under conditions of monotherapy.

In case of missed medication intake, the health-care consumer must take the remedy as soon as this omission is discovered. It is not required to take a double daily dose of the medicine in this case.

A daily dosage of this product should be 50 mg for those patients who suffer from moderate kidney dysfunction and who have CA level of 30-50 ml/min. In case of severe renal dysfunction, when CA level is below 30 ml/min, the daily amount of the medicine equals to 25 mg. Administration of Januvia by these patients does not depend on the time of the hemodialysis session.


In the Januvia leaflet it is indicated that its administration has to be performed in accordance with following scheme:

If the patient is diagnosed with kidney function disorder, the dosage should be reduced to fifty milligrams. In case of severe kidney function problems, the allowed dosage should not exceed twenty five milligrams of the active substance.

Use of this pharmaceutical product is allowed only as prescribed by a medical specialist.

Patients at the age of 65 years and above who are diagnosed with type II pancreatic diabetes can take the remedy without any restrictions as recommended by the attending physician. There can be complications resulting in the development of renal function disorder, as the disease worsens in late adulthood. In such cases, dosage adjustment is mandatory.

The product is quickly absorbed and begins to act in an hour after intake; the maximum absorption time is four hours. The medication can be taken at any time of the day, regardless of the meal. The medication is well absorbed. About 80% of the components of the drug are excreted from the body together with urine. Already in a week after taking the medication, there significant improvements in the treatment of the disease are observed.


  • This medicine has much fewer negative effects as compared to other sugar-reducing drugs.
  • The active ingredient is easily tolerated by the body, with practically no adverse reactions.

However still, there can be such adverse reactions as:

  • nasopharyngitis;
  • headache;
  • bouts of nausea;
  • abdominal pain;
  • upset stomach.

In case these symptoms are manifested the patient should consult a doctor to find out how dangerous they are. Sometimes a specialist is forced to cancel this drug because of these reactions.

As a rule, such negative effects disappear immediately after the agent is canceled.


Januvia is a remedy which must be taken with strict adherence to the prescribed dosage. Excessive intake of the agent can cause a number of complications and significantly worsen the person’s well-being. The minimum safe dosage is 80 mg. Clinical trials for overdose studies were conducted with a maximum amount of 800 mg.

In cases of overdose, which is expressed in an acute attack of hypoglycemia, headaches, nausea and vomiting, weakness, reduced general condition, it is necessary to extract the components of the drug from the gastrointestinal tract, using absorption methods. The drug therapy depending on the symptoms is intended to stop the clinical picture of an overdose.

According to clinical studies, intoxication is extremely rare. A reduced general condition in most cases is associated with the constitutional peculiarity of an individual or improperly selected complex therapy, which cannot be used with described remedy.

The pharmaceutical product is dialyzed in a minimal amount. According to laboratory tests, less than 13% of a single maximum dosage of the remedy has been excreted during the entire dialysis procedure, which lasted four hours.


Sitagliptin-based products do not inhibit the isozymes CYP2S8, CYP3A4, CYP2C9. In addition, the preparations do not inhibit such enzymes as CYP1A2, CYP2D6, CYP2B6, CYP2C19.

The Sitagliptin and Metformin combination does not have a significant impact on the Sitagliptin pharmacokinetics.

Medication must not be taken with cardiac glycoside Digoxin, as this may cause an increase in the Januvia's components concentration in the body. In case of concomitant intake of this product with such strong immunosuppressant as Cyclosporine, an increase of Sitagliptin level in the body has been observed.


The medication cannot be used together with alcohol-containing beverages, as during administration of hypoglycemic preparations there is an unpredictable decrease in blood glucose and other symptomatic signs observed.


Doctors all over the world are optimistic about Januvia: fasting glycemia is close to ideal levels; postprandial glucose levels do not exceed acceptable limits when dieting; intensive changes in sugars are not observed; the drug is safe and effective and fully meets the indicated criteria.

Here are the responses of some patients with suffering from this disease:

Sergio: When I took Januvia for the first time the blood sugar level decreased significantly, but after a while the indexes became high again. The doctor recommended remaining on the therapy and this jump he explained with my noncompliance with a diet. As soon as I refused the offending food products and continued taking the medicine the glucose level became normal again.

Tom: I used different tablets and administered injections but glucose level has never been stable and sometimes reached 14. But when I started taking Januvia, the glucose level dropped to 6. It happened for the first time only on this pharmaceutical product therapy. I continue using these pills and stick to a diet so that to keep glucose in the normal level.

Emma: I used to take Diabeton 1 tablet in the morning. Very often, blood sugar dropped to 3, due to which I always felt very bad. The endocrinologist changed Diabeton for Januvia. I felt better immediately. The blood sugar ceased to fall, and its level became much higher even during the day. Actually the price to quality ratio is quite good, however sometimes we have to consider other factors, not only economy.

Anna: I take Januvia 100mg in the morning. I feel great! Blood sugar is not higher than 7. Two weeks ago I did Glycated hemoglobin test and the result was 6, 9%. Just a great result! As for me, this is the best hypoglycemic medication!

Anton: The drug is very good – sugar is normalized, the weight comes back to normal, there is no feeling of hunger when there is a delay in meals. The drug is, of course, expensive, not everyone can afford such a drug, but if there is a possibility, you should try. It is awesome.


Januvia (Sitagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.
Active Ingredient: Sitagliptin Phosphate
Dosage Form: Tablet
Dosage: 100 mg Tablet;
Minimum Market Price: $3.99
Review: 1
Minimum Market Price