Generic Xyzal

Generic Xyzal
Xyzal is a drug utilized to deal with a wide range of allergies. Being an antihistamine, the drug is used to fight the effects of histamines, which are chemicals produced naturally by the human body.
Active Ingredient: Levocetirizine
Dosage Form: Tablet
Dosage: 5mg
Minimum Market Price: 0.5


Xyzal is an antihistamine medication primarily used for the treatment of allergy symptoms. The active ingredient in Xyzal is levocetirizine dihydrochloride. It is available in both branded and generic forms, including the Xyzal 5 mg tablet, Generic Xyzal allergy medicine, and children's Xyzal formulations. It belongs to a class of drugs known as antihistamines, which function by blocking the action of histamine, a substance in the body that causes allergic symptoms.

Xyzal, known generically as Levocetirizine, is a selective, potent, oral H1 receptor antagonist. It is primarily used for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. Levocetirizine demonstrates efficacy in allergic conditions due to its rapid onset and long duration of antihistaminic effect, with a notable absence of significant effects on cognition, psychomotor function, and the cardiovascular system.

General Instructions

Xyzal should be taken as directed by a healthcare provider. The medication can be taken with or without food. It is important to follow the prescribed dosage and not to take more than the recommended amount. The tablets should not be chewed or crushed but swallowed whole. For reducing sleepiness, it may be best taken in the evening.

The medication is available in tablet and liquid form. The liquid form of Xyzal must be measured accurately using a measuring cup or a spoon to ensure that you are receiving the required dosage. The drug is normally taken once a day.

The efficacy of the medication is assured irrespective of the method of administration. It is critical for caregivers to recognize that the pharmacokinetics of Xyzal in pediatric patients differ significantly from adults. Specifically, children's bodies exhibit a higher absorption rate, approximately twice that of an adult, for the same dosage of Xyzal. Consequently, it is imperative to adhere strictly to the prescribed dosage for children to avoid the risk of adverse health reactions. Furthermore, the administration of Xyzal in pediatric populations should only be undertaken following explicit medical authorization, underscoring the necessity of professional healthcare guidance in these cases.

Side Effects

The pharmacological profile of Xyzal (levocetirizine dihydrochloride), a widely prescribed antihistamine, includes several common adverse reactions. Notable among these are somnolence, asthenia, and xerostomia. Additionally, a subset of patients may report cephalalgia, pharyngitis, or coughing.

Levocetirizine dihydrochloride, commercially known as Xyzal Generic, is routinely administered by healthcare professionals for the amelioration of allergic manifestations, such as pruritus and lacrimation. The primary mechanism of action of this therapeutic agent involves the attenuation of histamine activity, a naturally occurring compound in the human body. Although Xyzal is efficacious in mitigating histamine-mediated responses, it is not devoid of adverse effects. The spectrum and severity of these side effects are subject to individual variability. Notably, certain predisposing factors, including concurrent medical conditions and the concomitant use of specific pharmacological agents, can influence the patient's response to Xyzal tablet. This underscores the importance of medical consultation prior to the initiation of levocetirizine therapy, notwithstanding its availability as an over-the-counter medication.

Extended administration of Xyzal has not been correlated with significant sedative effects or impairment in psychomotor functions. However, on rare occasions, severe hypersensitivity reactions may occur. Such instances warrant immediate clinical intervention. The occurrence of these serious adverse effects, although infrequent, necessitates vigilance and prompt medical attention.


Xyzal is used to relieve allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and hives. It is effective in treating both seasonal and year-round allergies.

The primary indication for Xyzal is the treatment of both seasonal and perennial allergic rhinitis, characterized by symptoms such as nasal congestion, rhinorrhea, sneezing, nasal itching, and ocular pruritus. By mitigating the histamine-driven allergic response, Xyzal effectively alleviates these discomforting manifestations.

Additionally, Xyzal is employed in the therapeutic regimen for chronic idiopathic urticaria, offering symptomatic relief from persistent hives and associated pruritus. Its efficacy in reducing the intensity and frequency of these cutaneous eruptions makes it a valuable option in the management of this condition.

In pediatric populations, children's Xyzal is specifically formulated to address the delicate needs of younger patients suffering from allergic symptoms. The medication's ability to control allergic reactions while maintaining a favorable safety profile makes it suitable for use in children, albeit under medical supervision.

Furthermore, Xyzal's role extends to the prophylactic treatment of allergic reactions. Patients predisposed to allergen exposure, particularly during peak pollen seasons, may benefit from the preemptive use of Xyzal to curb the onset of allergic symptoms.

In summary, Xyzal, both in its generic and branded forms, stands as a versatile medication in the arsenal against a spectrum of allergic conditions, offering relief from the discomfort associated with allergic rhinitis and chronic urticaria, and serving as a preventive measure in individuals prone to allergic reactions. Its application in both adult and pediatric care underscores its broad therapeutic utility in allergy management.


Caution should be exercised in patients with kidney problems, as dose adjustment may be necessary. Xyzal may impair thinking or reactions, so individuals should be cautious while driving or performing tasks requiring alertness. It is also important to discuss any other medical conditions with a healthcare provider before starting this medication.

What is Xyzal?

Xyzal is an over-the-counter medication used for the relief of allergy symptoms. It contains levocetirizine, an antihistamine, which helps reduce symptoms like runny nose, sneezing, itchy or watery eyes, and itching of the nose or throat.

How does Xyzal work?

Xyzal works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It helps alleviate symptoms by preventing histamine from binding to its receptors in the body.

What are the common uses of Xyzal?

Xyzal is commonly used to treat symptoms of seasonal and year-round allergies, including sneezing, runny nose, watery eyes, and itching of the nose or throat. It can also be used to treat symptoms of chronic urticaria (hives).

What are the possible side effects of Xyzal?

Common side effects of Xyzal include drowsiness, tiredness, and dry mouth. In some cases, it may cause more serious side effects such as difficulty in urinating, vision changes, or an allergic reaction.

Can Xyzal be taken with other medications?

Xyzal can interact with certain medications, so it's important to inform your healthcare provider about all medications and supplements you are taking before starting Xyzal.

How should Xyzal be taken?

Xyzal should be taken exactly as prescribed by your healthcare provider. It is usually taken in the evening, with or without food. The tablet should be swallowed whole with a glass of water.

Is Xyzal safe for children?

Xyzal is approved for use in children aged 6 years and older for the treatment of allergy symptoms and chronic hives. However, it's important to consult a pediatrician before giving Xyzal to a child.

Can I use Xyzal for a cold?

Xyzal is not intended for the treatment of common cold symptoms. It is specifically designed to treat allergy symptoms. For cold symptoms, other medications may be more appropriate.

Does Xyzal cause drowsiness?

Xyzal can cause drowsiness in some individuals, although it's generally considered a non-sedating antihistamine. It's advisable not to drive or operate heavy machinery until you know how Xyzal affects you.

How long can I take Xyzal?

The duration of treatment with Xyzal depends on the nature and severity of your symptoms. It's important to follow the advice of your healthcare provider regarding the length of treatment with Xyzal.

When Not to Use?

Levocetirizine dihydrochloride, marketed as Xyzal, is contraindicated in individuals exhibiting a documented hypersensitivity to levocetirizine or any constituent of the formulation. This contraindication extends to those with a known hypersensitivity to cetirizine, due to the close chemical relationship between these two compounds.

Furthermore, the use of Xyzal is contraindicated in patients suffering from severe renal impairment (glomerular filtration rate < 30 mL/min). This caution is due to the drug's primary excretion through the kidneys, where impaired renal function can lead to accumulation and increased risk of adverse effects.

Pregnant or lactating women are advised to seek medical counsel prior to the initiation of Xyzal therapy. Given the limited data on the teratogenic effects of levocetirizine and its excretion into breast milk, a risk-benefit assessment by a healthcare professional is necessary.

Additionally, individuals engaged in tasks necessitating heightened alertness, such as operating motor vehicles, handling heavy machinery, or performing complex tasks, should exercise caution or avoid the use of Xyzal. This recommendation is based on the medication's potential to induce somnolence, which could impair cognitive and motor functions, thereby increasing the risk of accidents or errors in these activities.


Xyzal may cause drowsiness and impair mental or physical abilities required for performing tasks. Caution is advised when engaging in such activities while taking this medication.

The use of alcohol or other central nervous system depressants can enhance the drowsiness effect of Xyzal. Patients should be aware of this interaction and avoid such substances while taking the medication.


The standard adult dose of Xyzal is 5 mg once daily in the evening. For children, the dose should be determined by a healthcare provider. The medication comes in both pill and liquid forms to accommodate different age groups and preferences. Dosage adjustments may be necessary for patients with kidney impairment.


Xyzal can interact with other medications, including certain sedatives and muscle relaxants. Alcohol or other central nervous system depressants can increase the drowsiness effect of Xyzal. Patients should inform their healthcare provider of all medications and supplements they are taking.

Patients are advised to provide a comprehensive list of their current pharmacotherapy regimen to their healthcare provider, encompassing all prescription and over-the-counter medications, as well as dietary supplements. This information is crucial for mitigating the risk of adverse drug interactions.

Furthermore, patients currently undergoing treatment with Xyzal are strongly advised against the consumption of alcoholic beverages. The concurrent use of alcohol can significantly intensify the sedative effects of levocetirizine, thereby compounding the risk of impaired alertness and motor coordination, which could have detrimental consequences.

Other Details

Storage Recommendations: Levocetirizine dihydrochloride, known as Xyzal, should be stored under controlled room temperature conditions, ideally away from excessive moisture and heat sources to maintain its stability and efficacy. It is imperative to keep this medication out of the reach of children to prevent accidental ingestion. Additionally, the use of Xyzal post its expiration date is not recommended due to the potential decrease in effectiveness and safety.

Levocetirizine in Pediatric Allergy Management: The administration of Xyzal for pediatric allergies necessitates precise dosing based on the child's age. For children aged between six months to five years, the dosage is restricted to 1.25 mg once every 24 hours. For the age group of six to eleven years, the recommended dose is increased to 2.5 mg daily. In adolescents aged twelve years and above, the dosage aligns with adult recommendations, typically 5 mg of Xyzal daily. Levocetirizine is contraindicated for use in infants under the age of six months.

Levocetirizine Use in Canine Allergies: Regarding the veterinary application, Xyzal has been recognized as an option among antihistamines for use in dogs, particularly for conditions like eosinophilic inflammation. While some veterinarians may prefer cetirizine (Zyrtec) over levocetirizine for canine patients, there have been instances where Xyzal has been successfully utilized. However, comprehensive studies on the effects of Xyzal in canine subjects are limited. Thus, veterinary consultation is essential prior to administering Xyzal to dogs. Special caution is advised in cases where the canine has pre-existing hepatic or renal conditions, given the potential for altered pharmacokinetics and pharmacodynamics in such scenarios.


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