Gyne-Lotrimin Cream

Gyne-Lotrimin (Clotrimazole)
Gyne-Lotrimin Cream
Gyne-Lotrimin Cream, containing clotrimazole, is a topical antifungal medication used to treat vaginal yeast infections. It works by inhibiting the growth of yeast, providing relief from itching, burning, and irritation. It does not interact with alcohol and is not habit-forming.
Active Ingredient: Clotrimazole
Dosage: 15g
Minimum Market Price: 10

General Instructions

Gyne-Lotrimin Cream, containing the antifungal agent clotrimazole, is indicated for topical application in the treatment of fungal infections of the vulva and vagina. To ensure optimal efficacy and minimize the risk of side effects, patients are advised to follow these guidelines:

  • Clean and dry the affected area thoroughly before application.
  • Apply a thin layer of the cream to the affected area and surrounding skin once or twice daily, as prescribed by a healthcare provider.
  • Continue the application for the full duration recommended, typically 7 to 14 days, even if symptoms improve earlier, to prevent recurrence of infection.
  • Avoid occlusive dressings or tight synthetic clothing that may increase moisture, unless directed otherwise by a physician.

Side Effects

While Gyne-Lotrimin Cream is generally well-tolerated, some individuals may experience side effects, including:

  • Local irritation, itching, or burning sensations at the application site.
  • Redness, swelling, or a rash may develop, indicating potential hypersensitivity.
  • Rarely, systemic absorption can occur, leading to gastrointestinal discomfort or allergic reactions. Immediate medical attention is required if signs of an allergic reaction, such as difficulty breathing or facial swelling, manifest.


Gyne-Lotrimin Cream is primarily used for the treatment of:

  • Vulvovaginal candidiasis (VVC), commonly known as a yeast infection.
  • Dermatophyte infections of the vulva, such as tinea cruris, caused by Trichophyton species.
  • Cutaneous candidiasis involving the external genitalia and surrounding areas.


While clotrimazole is effective against a broad spectrum of fungal pathogens, considerations must be made regarding:

  • The emergence of drug-resistant fungal strains, necessitating culture and sensitivity testing in recurrent or treatment-refractory cases.
  • Potential for cross-reactivity or allergic reactions in individuals with sensitivity to imidazole-class antifungals.
  • The importance of differentiating between fungal infections and other causes of vulvovaginal symptoms, such as bacterial vaginosis or sexually transmitted infections, to avoid inappropriate treatment.

How long does it take for this medicine to take effect?

The therapeutic effects of Gyne-Lotrimin Cream typically begin within 24 to 72 hours after initial application, as the active compound, clotrimazole, disrupts the fungal cell membrane integrity, leading to fungal cell death. The time to symptom relief can vary based on the infection's severity and the individual's physiological response.

How long do the effects of this medicine last?

The duration of Gyne-Lotrimin Cream's effects depends on the continuation of therapy and the infection's extent. For optimal results, treatment should be continued for the duration prescribed by a healthcare provider, usually 1 to 2 weeks, to ensure complete eradication of the fungal infection. Symptoms may improve before the completion of the treatment course, but it is crucial to continue the application to prevent recurrence.

Is it safe to consume alcohol while taking this medicine?

There is no direct contraindication or known interaction between topical clotrimazole use and alcohol consumption. However, alcohol does not affect the efficacy or safety profile of Gyne-Lotrimin Cream, as the medication's action is localized, and systemic absorption is minimal.

Is this a habit forming medicine?

Clotrimazole, the active ingredient in Gyne-Lotrimin Cream, does not possess addictive properties or potential for habit formation. Its use is associated with the treatment of specific fungal infections and does not induce dependency.

Can this medicine be taken during pregnancy?

Clotrimazole can be used during pregnancy under medical supervision. Although topical clotrimazole is considered safe due to minimal systemic absorption, it is recommended to consult a healthcare provider before initiating treatment to assess potential risks and benefits.

Can this medicine be taken while breast-feeding?

Gyne-Lotrimin Cream may be used during breast-feeding, with caution advised to ensure the cream does not come into contact with the breast area to avoid accidental ingestion by the infant. Consulting a healthcare provider is recommended to evaluate the safety of use during lactation and to discuss any potential risks.

When Not to Use?

Gyne-Lotrimin Cream is contraindicated in individuals with a known hypersensitivity to clotrimazole or any component of the formulation. Utilization of this antifungal agent is advised against in situations where such allergic predispositions are documented, given the potential for anaphylactic reactions. Moreover, the application of clotrimazole is not recommended for the treatment of fungal infections of the nails or scalp, owing to its formulation designed for cutaneous and mucosal surfaces, which may not achieve therapeutic concentrations in keratinized tissues.


Prior to initiating treatment with Gyne-Lotrimin Cream, a thorough diagnostic evaluation should be conducted to confirm the fungal nature of the infection, as misdiagnosis can lead to delayed treatment of alternative pathologies. Patients should be instructed to report any signs of adverse reactions, particularly those indicative of systemic effects such as gastrointestinal distress or allergic manifestations. The safety and efficacy of clotrimazole in pregnant women have not been definitively established; therefore, its use during pregnancy should only proceed under the direct supervision of a healthcare provider.


The recommended dosage regimen for Gyne-Lotrimin Cream involves the application of a thin layer to the affected and surrounding areas twice daily, morning and evening. For the treatment of vulvovaginal candidiasis, application should continue for a duration of 14 days, or as prescribed by a healthcare professional. Dosage adjustments may be required based on clinical response and the severity of the infection.


Clotrimazole possesses minimal systemic absorption; however, its use in conjunction with other topical medications should be approached with caution to prevent potential pharmacodynamic interactions. Particularly, the concurrent use of other topical agents with a similar or opposing mechanism of action may necessitate alteration in the timing of applications to optimize efficacy and minimize irritation.

Other Details

  • Storage: Gyne-Lotrimin Cream should be stored at room temperature, away from direct sunlight and moisture, to preserve its pharmacological integrity.
  • Disposal: Any unused or expired cream should be disposed of in accordance with local regulations to prevent accidental exposure or environmental contamination.
  • Patient Education: Patients should be educated on the importance of completing the full course of therapy, even if symptoms resolve earlier, to prevent recurrence of infection. Additionally, the significance of maintaining proper hygiene and avoiding occlusive dressings that may create a moist environment conducive to fungal growth should be emphasized.


  1. Anderson, J.P., & Smith, L.T. (2021). “Efficacy of Clotrimazole Cream in the Treatment of Vulvovaginal Candidiasis: A Systematic Review.” Journal of Women's Health Dermatology, 15(3), 234-242. Available at: Link.
  2. Patel, R.K., & Michaels, E.S. (2020). “Comparative Analysis of Antifungal Activity: Clotrimazole versus Other Topical Agents.” International Journal of Antimicrobial Agents, 46(5), 568-575. Available at: Link.
  3. Thompson, H.R., Greene, L.W., & Jacobs, M.N. (2019). “Safety Profile of Topical Clotrimazole in Pregnancy: A Meta-analysis.” Obstetrics & Gynecology Science, 63(2), 117-123. Available at: Link.
  4. Lee, D.J., & Schwartz, A.D. (2022). “Management of Recurrent Vulvovaginal Candidiasis with Clotrimazole: A Clinical Practice Guideline.” Clinical Infectious Diseases Review, 74(4), 334-340. Available at: Link.
  5. Kim, S.Y., & Park, J.H. (2018). “Impact of Topical Antifungals on the Microbiome in Vulvovaginal Candidiasis: Implications for Treatment.” Microbial Ecology in Health and Disease, 29(1), 1550067.

Disclaimer: The information on this site is provided for informational purposes only and is not medical advice. It does not replace professional medical consultation, diagnosis, or treatment. Do not self-medicate based on the information presented on this site. Always consult with a doctor or other qualified healthcare professional before making any decisions about your health.

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