Janumet helps to lower blood sugar levels in patients with type 2 diabetes mellitus along with diet and exercise. Janumet can be used alone, or in combination with insulin, or sulfonylurea medicines such as glimepiride, gliclazide and glibenclamide.
Active Ingredient: Metformin
Dosage Form: Tablet
Dosage: 50mg/500mg; 50mg/1000mg
Minimum Market Price: 0.1

General Information

How to treat type 2 diabetes? Treatment course implies not only pills, but also a change in the entire way of life. Diabetes mellitus type 2 is a condition when receptors don't accept insulin.

To put it simple insulin fits the receptor, which is on the surface of every cell of our entire body, as the key fits the lock. For certain reasons, this receptor-lock is broken, and the insulin key cannot open it, but it is really necessary to let glucose enter the cells, as it is the main fuel of our body.

However, since insulin does not do its job, meaning it does not deliver glucose to the cells, the glucose also accumulates in the blood, and this is an additional stimulus for the pancreas to start producing even more insulin.

What is Janumet?

Janumet is a prescription medication used to manage blood sugar levels in people with type 2 diabetes. It combines two medications: metformin and sitagliptin. Metformin helps reduce glucose production in the liver, while sitagliptin works by increasing the levels of insulin produced by the pancreas.

How should Janumet be taken?

Janumet should be taken orally with meals to reduce gastrointestinal side effects. The dosage is based on the patient's medical condition, response to treatment, and other medications they may be taking.

What are the side effects of Janumet?

Common side effects of Janumet include nausea, vomiting, stomach upset, diarrhea, and headache. More serious side effects can include the development of pancreatitis, changes in blood sugar levels, and a rare but serious condition called lactic acidosis.

Who should not take Janumet?

People with severe kidney disease, metabolic acidosis, or diabetic ketoacidosis should not take Janumet. Also, it should be used cautiously in those with liver disease, alcoholism, or heart failure.

Does Janumet interact with other medications?

Yes, Janumet can interact with other medications, such as certain blood pressure medications, diuretics, and corticosteroids. It's important to inform your healthcare provider about all the medications and supplements you are taking.

Can Janumet cause weight gain?

Janumet is not typically associated with weight gain. In fact, the metformin component may help with weight loss in some people.

How does Janumet help in managing type 2 diabetes?

Janumet helps in managing type 2 diabetes by improving insulin sensitivity, decreasing glucose production in the liver, and increasing insulin secretion, thereby helping to control blood sugar levels more effectively.

Can Janumet be used in combination with other diabetes medications?

Janumet can be used in combination with other diabetes medications, but only under the guidance of a healthcare provider, as it may require adjustments in dosages to effectively manage blood sugar levels.

Is it necessary to monitor blood sugar levels while taking Janumet?

Yes, regular monitoring of blood sugar levels is important while taking Janumet to ensure effective management of type 2 diabetes and to adjust the medication dose if necessary.

Does Janumet need to be taken lifelong for type 2 diabetes?

Type 2 diabetes is a chronic condition, and Janumet may need to be taken long-term as part of the overall management plan, which also includes diet, exercise, and possibly other medications.

Insulin resistance

Typically, insulin resistance is most common in people who are overweight, but studies show that in 25% of cases it can also occur in people with normal body weight. This is a fact that not only obesity affects insulin sensitivity.

In addition to obesity, there are following causes for the insulin resistance development:

  • smoking
  • taking certain medications (glucocorticoids, thiazide diuretics, beta-blockers for the cure of hypertension and heartbeat)
  • low physical activity
  • genetic defects of the receptor
  • obesity plays a leading role in the development of insulin resistance

After gaining 35-40% of the standard weight the insulin sensitivity decreases by 40%. This fact is proved by numerous studies.

To treat this disease, there are many popuar methods, including diet, sport exercises, getting rid of smoking as well as a therapy course.

You can treat diabetes mellitus type 2 with both blood glucose lowering drugs and insulin. There are many antidiabetic drugs against of type 2 diabetes today. One of them is Janumet XR.

Due to effect of Metformin and Sitagliptin, which are two key elements of the remedy, the hypoglycemic action of this pharmaceutical product is enchasing substantially. They complement each other, reducing the blood sugar level.

Sitagliptin is a DPP-4 inhibitor, activating incretins, which, in turn regulate glucose homeostasis. When there is a need help to improve the insulin secretion. This suppresses the release of glucagon and, as a consequence, the synthesis of glucose in the liver.

Metformin is biguanide, which increases tolerance to glucose, and then reduces its concentration in the blood and synthesis in the liver.


Under certain conditions it is needed to be extremely careful when treating with Janumet (Metformin).

Acute pancreatitis. The physician has to warn the individual: in the presence of pain in the abdominal region or right upper quadrant, it is necessary to terminate the drug usage.

Lactat acid acidosis. It is a heavy and rather frequent condition leading to dangerously fatal consequences. In case of manifestations expression, you must interrupt therapy regimen. You will see it as respiratory embarrassment, epigastric pain, chills, dysemia, muscle spasms, asthenia, gastrointestinal tract disorders.

Renal pathologies. The lactat acid acidosis develops the risk to increase renal disorder that is why it is so vital to monitor the creatinine ratio. Especially it concerns diabetics of mature age, because renal disorders in them can proceed asymptomatically.
In case allergic symptoms manifestation, the medication must be withdrawn.

Surgery. If a diabetic intends for an operation, you should cancel Janumet treatment course two days before and the patient must be put for insulin therapy.

Iodine-containing products. When iodine-containing remedy is taken together with Janumet, it can provoke a renal system problem.

Moreover, there are additional contraindications preventing use of Janumet (Metformin):

  • Ketoacidosis
  • Kussmaul's coma
  • Infectious diseases
  • Shock states
  • Diseases provoking hypoxia in tissues
  • Liver dysfunction, poisoning, alcohol abuse
  • Pregnancy including breastfeeding
  • Type I diabetes.
  • Age under 18 years

We must mention, that since the main excretion pathway of Sitagliptin and Metformin lies through the renal system, and due to the fact that excretion function of the kidneys reduces with age, the doctor prescribing Janumet (Metformin) must take this aspect into account. The dosage for elderly patients must be carefully adjusted and they have to be under close supervision of treating physician.

What is Metformin?

Generic Janumet (Sitagliptin Metformin) does not affect the ability to manage vehicles or complex mechanisms, but Synagliptin can result in weakness and drowsiness.

Metformin Dose

You can select the Janumet dose schedule basing on individual characteristics, as well as when applying treatment course, effectiveness and tolerance, but you better not exceed the highest daily dose amounting to 100 mg of Sitagliptin.

Adverse reactions:

Digestive tract disorder: at the start of the treatment, there can be such manifestations as abepithymia, diarrhea, sickness, retching, flatus, celialgia (diminishing during food intake); metallic aftertaste in the mouth (3%).

Heart-vascular and blood system (hematopoiesis, blood stasis): in separate events megaloblastic anemia can develop (as a result of vitamin B12 and folic acid malabsorption).

Metabolism: glucopenia; in some cases lacticacidemia can develop (resistant bradyarrhythmia, fragility, hypersomnia, arterial hypotension, respiratory disorders, stomach pain, myodynia, hypothermy).

Reactions which you might experience:

  • Skin: eruption, scytitis
  • Headaches
  • Pancreatitis
  • Nausea, abdominal pain
  • Anorexia
  • Metallic taste in the mouth
  • Vomiting
  • Diarrhea or constipation
  • Dry mouth
  • Allergic reactions
  • Drowsiness
  • Cough
  • Anemia
  • Lactic acidosis
  • Hypoglycemia
  • Peripheral edema


The lactoacidosis may develop in case of overdose. In this case, it is better to remove the drug remnants from the body, then hemodialysis shall be carried out and the patient's condition must be under the control.

Symptoms of hypoglycemia are also possible. In case of a light form, doctors reccomend to take a meal rich in carbohydrates.


Concomitant diseases require correction of a special treatment strategy. If they are available, it is necessary to combat several pathologies at once, accordingly, there is a need for combining different medications.

There are several drugs, which can change the effectiveness if you use them together. Among them are: Furosemide; Nifedipine; Digoxin; Cyclosporin; Januvia.

Metformin and Alcohol

This product is not compatible with alcohol, since ethanol affects its efficiency.

Respond: 8
  1. I was prescribed Janumet (Metformin) by my doctor. During 2 years I take 2 tablets
    a day. My doctor and I are satisfied with its action: the sugar level is stable, and my
    overall health condition has been improved. The medication is rather expensive, but, in
    my opinion, it is the one of the best.

    • It’s great to hear that Janumet (Metformin) has been prescribed by your doctor and has proven effective for stabilizing your sugar levels and improving your overall health condition over a period of 2 years. While it may be expensive, the positive results and satisfaction you and your doctor have observed make it worth considering as one of the best options for you. It’s important to continue following your doctor’s guidance and regularly monitor your health.

  2. Yes, it is irreplaceable now (there are no complete analogs) drug for diabetes
    mellitus with very high proven efficacy.

    • It’s true that Janumet is considered an irreplaceable and highly effective medication for diabetes mellitus, with proven efficacy. Its unique combination of ingredients sets it apart from other alternatives in the market. However, it’s always recommended to consult with a healthcare professional for personalized advice and to consider individual circumstances.

  3. I tried this medicine for the first time. In combination with physical work and tablets, I also lost 12 kg in 1.5 months. I’m very happy with the drugs, although it’s expensive.

    • It’s positive to hear that Janumet, along with physical activity, has not only helped in managing your diabetes but also contributed to weight loss. Losing 12 kg in 1.5 months is a significant accomplishment, and it’s great that you are happy with the medication’s effectiveness, even though it may be expensive. It’s essential to discuss any concerns about the cost of medication with your healthcare provider to explore potential options.

  4. 26.09.2019 17:09

    I’ll always recommend this pill to diabetic patients because it helped in reducing my blood sugar level. It is a very effective and efficient drug. It is really worth every penny to purchase.

    • Thank you for sharing your recommendation based on personal experience with Janumet. It’s valuable to hear that it has been effective in reducing your blood sugar levels and that you find it to be a very efficient and worthwhile drug. Each individual may respond differently to medications, so it’s important for others to consult with their healthcare professionals for personalized advice and guidance.

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