Generic Melatonin (Melatonin)

Generic Melatonin
Everyone knows that Melatonin is a sleep hormone which is the strongest natural immunomodulator, which mainly produced by the pineal gland. These days there exists a synthetic analog of this agent which is called also Melatonin. It is not a pharmacological agent and can be classified as a biologically active supplement.
Active Ingredient: Melatonin
Dosage Form: Tablet
Dosage: 3 mg Tablet; 5 mg Tablet; 10 mg Tablet;
Minimum Market Price: $0.24

General information

Melatonin is a sleep hormone. It is a natural sleeping aid, antioxidant and immunomodulatory agent. It is called the elixir of youth, beauty and health. It can significantly improve the quality of human life. Clinical studies of Melatonin have shown its effectiveness in the treatment of many diseases (from coronary heart disease to stomach ulcers).

Melatonin is produced by the pineal gland. The human body can contain up to 3 milligrams of this substance. The level of the substance in the human blood is variable. It is low during the day and high at night. Its blood concentration increases at twilight and reaches its maximum from midnight to 4.00 am and then begins to decrease. Melatonin begins to work after a person falls asleep. It restores and strengthens all human systems and organs. Melatonin is the strongest natural immunomodulator that absorbs free radicals. Free radicals are unstable molecules that destroy human DNA, cells, tissues and contribute to the development of cancer and heart diseases. Insomnia and excess light interferes with melatonin production. A person should sleep with curtains tightly closed, do not use night lights and do not turn on the bright lights at night.


The medicine called Melatonin is a synthetic analogue of the pineal gland hormone. This medicine is not a pharmacological agent. It can be classified as a biologically active supplement.

This medicine is used to treat insomnia, sleep disorders, delayed sleep phase syndrome and helps in the regulation of the biological “sleep-awakening” cycle with frequent time zone changes. This biologically active supplement is also used as an antioxidant to protect cells from the harmful effects of free radicals. It has a stimulating effect on the enzyme glutathione peroxidase, normalizes blood pressure, reduces cholesterol in the blood and has a positive effect on the premenstrual symptoms.

Melatonin is sold without a prescription as a dietary supplement. You can buy it at most pharmacies. The medicine is available in different forms. It is made in the form of conventional tablets or capsules. These can be pills that are slowly absorbed in the body over a long period of time. Using other sleeping pills is usually accompanied by various problems such as addiction. Therefore, the patient has to increase the dose. The biologically active supplement is the best alternative because it is not addictive.


This biologically active supplement is available in various forms and dosages. These can be tablets or capsules containing from 3 mg to 6 mg of active substance. The maximum dosage of the medicine should be no more than 6 mg per day.

How to take Melatonin?

This biologically active supplement is useful to all people over 35 years old. It is usually taken in courses of about 1-3 mg at night. The frequency of admission varies individually. For example, people suffering from insomnia should take Melatonin 3-4 times a week.

The medicine can be taken daily to treat serious sleep disorders. The dosage ranges from 3 mg to 6 mg per day (30 minutes before bedtime every day). The course of treatment is continued until the restoration of the physiological rhythm “sleep-wake” but not more than 1 month.
The dose and the course of administration are determined by the doctor if the medicine is used prophylactically. It depends on the individual characteristics of the person. This biologically active supplement is prescribed in the minimum effective dose of 1.5 mg (1/2 tablet) once a day 30 minutes before sleep to treat chronic sleep disorders in elderly patients. Drug withdrawal should be carried out gradually over 1-2 weeks.

The medicine can be used for 3-6 months with 1 week intervals between monthly courses of treatment. The duration of treatment is recommended to be limited to 13 weeks if the daily dose of the medicine is more than 3 mg.

The medicine is not prescribed if a person has the following diseases:

  • hypersensitivity to the active substance or other components of the drug;
  • lymphogranulomatosis;
  • autoimmune diseases;
  • chronic renal insufficiency;
  • myeloma;
  • leukemia;
  • lymphoma;
  • diabetes (the medicine is not combined with antidiabetic drugs);
  • epilepsy.


  • The medicine is contraindicated in pregnancy and lactation.

Important Information

  • It is necessary to carefully prescribe the medicine to patients with hormonal disorders and those whose work requires a high concentration of attention and a quick psychomotor reaction.
  • The medicine is contraindicated in children aged less than 16 years.
  • The medicine cannot be used as a part of complex treatment with MAO inhibitors and cyclosporine.
  • Persons under medical supervision (or taking sedatives or sleeping pills) should consult a physician before taking the medicine.
  • The drug has a weak contraceptive effect. Therefore, women who want to get pregnant should not use it.


This biologically active supplement causes side effects rarely. The following is a list of possible side effects:

  • irritability, nervousness, anxiety, unusual dreams, nightmares;
  • mood swings, aggression, tearfulness, symptoms of stress, disorientation, early morning awakening, increased libido, low mood, depression;
  • exacerbation of herpes zoster;
  • increased activity of hepatic transaminases;
  • abnormal content of electrolytes in the blood;
  • asthenia;
  • fatigue;
  • thirst;
  • pain in the limbs;
  • muscle spasm;
  • pain in the neck;
  • night cramps;
  • dermatitis;
  • eczema;
  • angioedema, swelling of the oral mucosa, tongue swelling;
  • angina, palpitations, hot flashes;
  • decrease in visual acuity, blurred vision, increased tearing.


  • Overdose of the medicine is rare. Overdose is expressed in enhancing the side effects of the drug.
  • Gastric lavage and symptomatic therapy should be carried out in case of an accidental overdose of the drug.


Melatonin may affect the effectiveness of hormonal drugs (androgens, estrogens and etc.). This medicine can increase the binding of benzodiazepines to specific receptors, so their combined use requires medical monitoring. The drug potentiates the antitumor effect of tamoxifen. The dopaminergic and serotonergic effects of methamphetamines can be enhanced while being used with Melatonin. The medicine potentiates the antibacterial action of isoniazid.

Alcohol interaction

Alcohol can cause serious complications when taken in combination with Melatonin. In addition, alcohol disrupts sleep and melatonin loses its effectiveness. A person taking alcohol with combination of melatonin may have different side effects. This can lead to health problems and accidents.

Common side effects with co-ingestion of melatonin and alcohol are:

  • poor sleep;
  • irritability;
  • confusional state;
  • increased anxiety;
  • redness of the face;
  • swelling of the legs and arms;
  • tachycardia.


Doctor’s reviews

Dr. Jackson: This medicine is an effective somnifacient of natural origin. Insomnia is a result of an insufficient amount of melatonin in a human blood. The use of the medicine helps to cope with this problem. The medicine in addition to the regulation of the wake-sleep cycle ensures the effective functioning of the endocrine system. This active substance is included in the composition of dietary supplements for complex rejuvenation of the body. The drug also normalizes the circulatory system and heart. The risk of blood calculus in blood vessels increases significantly with an insufficient amount of melatonin. I often recommend this dietary supplement to my patients.

Dr. Brent Watson: Scientific studies show that a lack of melatonin leads to an acceleration of the aging process. Free radicals begin to damage the cells of the body. This decreases the body's sensitivity to insulin and increases the risk of developing cancer. Therefore, I recommend that all of my patients aged 50-60 take this drug. I recommend beginning the medicine with a dose of 1 mg. Then the patient should raise the dosage to 3 mg of the active substance. My patients never complained about side effects. Men and women noted an improvement in the quality of sleep and general well-being.

Reviews by Patients

Justin: I had trouble falling asleep. Sometimes I could not fall asleep until 4 in the morning and then I fell asleep and could not wake up. I constantly had a weariness, reduced working capacity, impaired mood and depression of life energy. I was advised to use medicines based on herbal ingredients. However, their actions were very weak. After that, I began to take this biologically active supplement but did not believe in its effectiveness because there were no results for the first 4 days. I fell asleep well on the fifth day of the medicine intake. I felt great after waking up and was very pleased with the effect. It is very important to take the drug at the same time of day (30 minutes before bedtime). I took the medicine for two weeks (two tablets at bedtime). After that, I took one pill for a night for a week. I did not notice the abstinence symptoms after the end of the medicine intake. About two months have passed and I sleep very well. The medicine helped me cope with insomnia. I can recommend this biologically active supplement to all people who are having trouble sleeping.

Clementine: My sleeping schedule was completely disturbed after the birth of a child. My daughter could wake up several times during the night. I was not able to fix my sleep even after the child began to sleep all night. I felt tired all day after a sleepless night. I began to take 2 capsules of the drug at bedtime. I began to fall asleep well on day 3 after taking the drug. I was finally able to adjust sleep patterns like all normal people. Melatonin helped me sleep for 9 hours and don't wake up with the slightest rustle. I ceased to have anxious dreams. I did not notice any side effects. On the contrary, I began to look younger and feel a full of energy. I can safely recommend this medicine to those who have trouble sleeping. It is a dietary supplement and is sold without a prescription. I bought it on the Internet.

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