Uses & Effectiveness
Overview
Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). It may be helpful for hay fever and weight loss.
Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting. It may also decrease pain and swelling, reduce levels of sugar in the blood, and help the body fight against disease.
Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. But there is no strong evidence to support resveratrol for any use.
Resveratrol, found in foods like red wine and grapes, has been linked to numerous health benefits. Studies suggest it may protect against heart disease, lower blood sugar levels, and even have anti-aging effects.
Side Effects
When taken by mouth: People often consume resveratrol in small amounts in foods. Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.
When applied to the skin: Resveratrol is possibly safe when used for up to 30 days.
When sprayed into the nose: Resveratrol is possibly safe when used for up to 4 weeks.
Interactions
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Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
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Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with RESVERATROL
Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
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Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
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Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
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Medications changed by the liver (Cytochrome P450 1B1 (CYP1B1) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
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Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
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Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with RESVERATROL
Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Moderate Interaction
Be cautious with this combination
Special Precautions and Warnings
Pregnancy and breast-feeding: Resveratrol is likely safe when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol when pregnant or breast-feeding.
Children: People often consume resveratrol in small amounts in foods. But there isn’t enough reliable information to know if it safe to take by mouth in larger amounts. Resveratrol is possibly safe in children when sprayed in the nose for up to 2 months.
Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use resveratrol.
Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.
