• QA
  • Drugs
    • Add to favorites
    • Here we have gathered useful information containing diseases and medications description. We did our best to provide you with answers to most frequently asked questions. Our experts and partners provide us with the necessary support being available on-line 24/7 to provide all the necessary clarifications.

    • Questions:
      31
  • Erectile Dysfunction
    • Add to favorites
    • It is the inability to achieve and maintain an erection sufficient to perform sexual intercourse. It is one of the most common sexual disorders in men.

    • Questions:
      57
  • General Health
    • Add to favorites
    • The level of the general health is determined depending by the presence and severity of the vital body functions decompensation. In accordance with this, the doctor takes a decision on urgency and necessity of therapeutic measures.

    • Questions:
      58

What is the most effective way to take Cialis?

Published at 10.02.2019 11:15
Erectile dysfunction (ED) is a chronic disease and is detected in 9.5% of 40-year-old men, reaching 71.2% prevalence in men aged 71–80 years. For the treatment of impotence different PDE-5 inhibitors are currently used.

Cialis has the highest half period compared with other remedies of this range and can be taken on demand at a dose of twenty milligram. It becomes effective in 16–30 minutes after the intake and the duration of its effect lasts up to thirty five hours. However, even with such a duration of action, the intake of the pill on demand only temporarily improves sexual function. In this regard, some sexologists observe and express concern that the planning of sexual activity associated with on-demand therapy for ED may negatively affect psychological condition and living standards of patients and their families, especially those for whom the spontaneity of relationships and/or round-the-clock efficiency plays a big role.

There is evidence that regular use of the medicine on experimental animals promotes partial regression of changes in the cavernous bodies and improvement of their oxygenation after selective bilateral neurotomy of the cavernous nerves. Thus, the concept of continuous daily intake of the drug has been actively discussed in recent years by various researchers.

With this therapeutic approach, it’s recommended to take 5 mg of Cialis 1 time per day, with a possible reduction of the dose to 2.5 mg, taking into account individual effectiveness and acceptability. The researchers found that after 5 days of continuous intake of this remedy in the blood plasma, a steady state of the medicine is achieved, able to develop and maintain the effect with little individual variability. An important advantage of this type of therapy is the possibility of using the medicine in combination with α – adrenoblockers without any dose adjustment. In addition, dose adjustment is not required in men with nephratonia and liver impairment, as well as in those who receive therapy with protease inhibitors (ritonavir) or the CYP3A4 enzyme system (for example, ketoconazole). However, daily administration of the drug is contraindicated for men with severe renal failure.

Efficacy and safety of therapy with this remedy at 1 time per day were evaluated in various studies in men with ED in both the general population and diabetics. Thus, according to the data of modern experimental and clinical studies, the therapy with Cialis in the dosage of 1 time a day is effective and safe, while the effectiveness doesn’t decrease with long-term use of the drug, and the frequency of side effects is comparable to that when taking Cialis on demand.

Add widgets to sidebar
Respond: 0
Views: 894