Dr. Steven David Mittelman, MD

Dr. Steven Mittelman is an Associate Professor of Pediatrics and Physiology & Biophysics in the Center for Endocrinology, Diabetes & Metabolism at the Keck School of Medicine, University of Southern California. He received his MD and PhD degrees from the Keck School of Medicine, where he worked on elucidating the physiological mechanisms by which insulin regulates blood sugar. Further work examined how pancreatic beta-cells compensate for obesity-induced insulin resistance, and how appetite regulating hormones work in obese adolescents. Steven completed his residency in pediatrics and fellowship in pediatric endocrinology at Children’s Hospital Los Angeles. During his subspecialty training, Steven learned of an important finding by researchers in the Children’s Center for Cancer and Blood Diseases: children who are obese when they are diagnosed with high-risk leukemia have a 50% higher chance of relapsing than those who are lean. In fact, obesity increases the risk of dying from many …different types of cancer, such as breast, colon, and prostate, and may be responsible for up to 15-20% of cancer deaths in the U.S. Dr. Mittelman turned his expertise in obesity into work exploring the relationships between obesity and leukemia relapse, in collaboration with Drs. Nora Heisterkamp and Anna Butturini. His laboratory is currently investigating how obesity and cancer interact, using both mouse models and tissue cultures. He has found evidence that fat tissue may absorb some chemotherapies, so that these drugs are not available to kill the cancer cells. He also found that fat cells play an active role in the cancer microenvironment, participating in a two-way communication with cancer cells, and producing metabolic fuels and survival factors which protect cancer cells from chemotherapies. These findings have led to multiple publications which have been well-received in both the scientific and lay press. Dr. Mittelman is currently investigating strategies to block some of these effects of adipocytes, in the hopes that this will lead to improvements in cancer survival in both thin and overweight people.

• Childrens Hospital Los Angeles

Ucla Health Westwood Pediatrics

200 UCLA Medical Plz Ste 265

Los Angeles

CA

90095

USA

+13108250867

• Endocrinology, Diabetes & Metabolism
• Pediatric Endocrinology
• Pediatrics

• Aetna Signature Administrators PPO
• Anthem BC Pathway X EPO Network
• BCBS Blue Card PPO
• Blue Cross CA Advantage PPO Preferred DirectAccess Plus
• Blue Shield CA Bronze Full PPO 4500
• Blue Cross CA Pathway X PPO
• Aetna HMO
• First Health PPO
• Blue Shield CA Silver 70 PPO
• PHCS PPO Kaiser
• Aetna Managed Choice POS Open Access
• Oscar Insurance CA
• CIGNA LocalPlus
• Blue Cross CA PPO Prudent Buyer Individual
• Multiplan PPO
• BS CA Platinum 90 PPO
• Blue Cross CA PPO Prudent Buyer Large Group
• Blue Cross CA PPO Prudent Buyer Small Group
• Aetna Choice POS II
• Aetna Savings Plus of CA
• CIGNA PPO
• CIGNA Open Access Plus
• CIGNA HMO
• UHC Choice Plus POS
• UHC Options PPO
• Blue Cross CA Select PPO
• PHCS PPO
• LACare
• Aetna HMO Deductible Plan CA only
• Blue Cross CA Vivity
• Aexcel PPO
• MEDICA CHOICE WITH UNITEDHEALTHC
• UHC Nexus Open Access
• Aetna Elect Choice EPO Open Access
• Aetna Innovation Health Aetna Premier Care Network Plus
• Aetna Open Choice PPO
• BCBS Pathway HMO
• Blue Shield CA Platinum 90 PPO
• Blue Shield of CA 2021 I&F PPO Plan
• LA Care
• Medica Choice With UHC
• Oscar Circle EPO CA
• Oscar Northern CA Cigna + Oscar Open Access Plus
• Oscar Southern CA Employee
• BCBS Pathway EPO
• Oscar CA Cigna + Oscar Open Access Plus
• Blue Shield CA PPO
• Blue Shield CA Access Plus HMO
• Blue Shield CA Bronze 60 PPO SHOP
• Blue Shield CA Platinum Access+ HMO 25
• Capital Blue Cross/Wellspan Health PPO
• Blue Cross CA Pathway EPO
• Blue Cross CA Pathway HMO
• UHC SignatureValue HMO - CA

• Diabetes Mellitus Disease (DM)