What is the most effective way to take Cialis?

Erectile dysfunction (ED) is a chronic disease. This diagnosis is usual in 9.5% of 40-year-old men, reaching 71.2% prevalence in men aged 71–80 years. For the treatment of impotence, doctors recommend using different PDE-5 inhibitors.

About the drug

Cialis has the highest half period compared with other remedies of this range and can be taken on-demand at a dose of twenty milligrams. It becomes effective in 16–30 minutes after the intake. The duration of its effect lasts up to thirty-five hours.

However, even with such a duration of action, the intake of the pill on-demand only temporarily improves sexual function.

Therapy for ED

So, some sexologists have a concern that sexual activity associated with on-demand therapy for ED may negatively affect patients and their families. First of all, this includes those for whom the spontaneity of relationships and/or round-the-clock efficiency plays a big role.

There is evidence that the medicine regular use promotes partial improvement in the cavernous bodies and of their oxygenation.

So in recent years, various researchers discuss the concept of continuous daily intake of the drug.

Dosages and effect

Specialists recommend taking 5 mg of Cialis 1 time per day, with a reduction of the dose to 2.5 mg. Above all, you must pay attention to individual effectiveness and acceptability of the drug.

The researchers found that after 5 days of continuous intake this drug is able to achieve a steady-state in the blood plasma. As a result, it develops and maintains the effect with little individual variability.

Advantages

An important advantage of this type of therapy is the possibility of using the medicine in combination with α – adrenoblockers without any dose adjustment.

Furthermore, there is no need for dose adjustment in men with nephratonia and liver impairment. Similarly in those who receive therapy with protease inhibitors (ritonavir) or the CYP3A4 enzyme system (for example, ketoconazole). However, men with severe renal failure should not administer the drug on a daily basis.

Efficacy of the drug

Efficacy and safety of therapy with this remedy at 1 time per day were evaluated in various studies in men with ED in both the general population and diabetics.

Thus, according to the data of modern experimental and clinical studies, the therapy with Cialis in the dosage of 1 time a day is effective and safe, while the effectiveness doesn’t decrease with long-term use of the drug, and the frequency of side effects is comparable to that when taking Cialis on demand.