Hypoparathyroidism is a medical condition characterized by the underproduction or dysfunction of parathyroid hormone (PTH), a hormone responsible for regulating calcium and phosphorus levels in the body.

Hypoparathyroidism – causes, symptoms, diagnosis, treatment, pathology

Individuals with hypoparathyroidism experience low levels of PTH, resulting in abnormally low levels of calcium and high levels of phosphorus in the blood. This imbalance can lead to various symptoms and complications.

The causes of hypoparathyroidism can vary, including damage or removal of the parathyroid glands during surgery, autoimmune disorders, genetic conditions, or as a result of other medical treatments or conditions.

Common symptoms of hypoparathyroidism include muscle cramps, tingling or numbness in the extremities, fatigue, weakness, dry hair and skin, and difficulty concentrating. In severe cases, individuals may also experience seizures, cataracts, or abnormal heart rhythms.

Treatment for hypoparathyroidism often involves taking calcium and vitamin D supplements to restore and maintain proper calcium levels in the body. Medications may also be prescribed to help manage symptoms and prevent complications.

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It is important for individuals with hypoparathyroidism to closely monitor their calcium levels, follow a calcium-rich diet, and regularly visit their healthcare provider for check-ups and adjustments in treatment plan.


  • Muscle cramps or twitching
  • Tingling or numbness in the fingertips, toes, or lips
  • Fatigue or weakness
  • Irritability or mood swings
  • Painful menstrual periods (in women)
  • Patches of dry skin or hair loss
  • Frequent headaches or migraines
  • Poor concentration or memory problems
  • Seizures or convulsions
  • Abdominal cramping or diarrhea


Hypoparathyroidism is a rare endocrine disorder characterized by the insufficient production of parathyroid hormone (PTH) by the parathyroid glands. The causes of hypoparathyroidism can include:

  • Autoimmune diseases, such as autoimmune polyglandular syndrome type 1 (APS-1) or isolated autoimmune hypoparathyroidism.
  • Surgical removal or damage to the parathyroid glands during thyroid or neck surgery.
  • Genetic or hereditary conditions, such as DiGeorge syndrome or Kenny-Caffey syndrome.
  • Radiation therapy to the head or neck area, which can affect the function of the parathyroid glands.
  • Medical treatments such as radioactive iodine therapy for hyperthyroidism.
  • Idiopathic hypoparathyroidism, where the exact cause is unknown.

It is important to note that this is just basic information, and a healthcare professional should be consulted for accurate diagnosis and personalized information.

Hypoparathyroidism Diagnosis


Hypoparathyroidism is a rare disorder characterized by abnormally low levels of parathyroid hormone (PTH), which can lead to an imbalance of calcium, phosphorus, and vitamin D in the body. Diagnosis of hypoparathyroidism usually involves a combination of medical history evaluation, physical examination, and laboratory tests.


Common symptoms of hypoparathyroidism may include muscle cramps, numbness or tingling in the fingertips, toes or lips, seizures, headaches, memory problems, and an abnormal heart rhythm (arrhythmia). However, symptoms can vary from person to person.

Diagnostic Methods

  • Medical History Evaluation

    The doctor will inquire about the patient's medical history, symptoms, and any previous medical conditions or surgeries that might be related to hypoparathyroidism.

  • Physical Examination

    A physical examination may involve assessing muscle strength, reflexes, and checking for any signs of low calcium levels, such as muscle spasms or tetany (repeated, uncontrollable muscle contractions).

  • Laboratory Tests

    Several blood tests can help diagnose hypoparathyroidism, such as:

    • Calcium and phosphorus level measurement
    • PTH level measurement
    • Vitamin D level measurement
    • Magnesium level measurement (as low magnesium levels can also contribute to hypoparathyroidism)
  • Genetic Testing

    In some cases, genetic testing may be recommended to identify any genetic mutations that could be causing or contributing to the condition.

  • Imaging Tests

    Imaging tests like ultrasound, CT scan, or MRI may be used to visualize the parathyroid glands and assess their structure or abnormalities.


Diagnosing hypoparathyroidism involves a comprehensive evaluation of medical history, physical examination, and specific laboratory or imaging tests. Proper diagnosis is crucial for implementing appropriate treatment and managing the condition effectively.