Myelodysplastic Syndrome: Basic Disease Information - iMedix

Myelodysplastic Syndrome is a condition where the bone marrow doesn’t make enough healthy blood cells, which can cause fatigue, frequent infections, and bleeding problems.

• Age-related changes: As people age, their bone marrow can become less efficient at producing blood cells, increasing the risk of MDS.
• Previous cancer treatments: Chemotherapy or radiation therapy for other cancers can damage the bone marrow and lead to MDS.
• Genetic predisposition: Some people may have a genetic risk for developing MDS.
• Exposure to harmful chemicals: Long-term exposure to chemicals like benzene or heavy metals can increase the risk of MDS.

• Age: MDS is most common in people over 65.
• Previous cancer treatments: Those who have undergone chemotherapy or radiation therapy may have a higher risk.
• Exposure to chemicals: Individuals with prolonged exposure to harmful chemicals, such as those in industrial workplaces, are at a higher risk.
• Genetics: A family history of MDS or similar blood disorders can increase the likelihood of developing the condition.

• Fatigue: A lack of healthy red blood cells can cause ongoing tiredness and weakness.
• Frequent infections: A low white blood cell count makes it harder for the body to fight off infections.
• Easy bruising or bleeding: Reduced platelets can lead to frequent bruising, nosebleeds, or prolonged bleeding from minor cuts.
• Shortness of breath: Anemia caused by a lack of red blood cells can result in difficulty breathing, especially during physical activity.
• Pale skin: A low red blood cell count may cause skin to appear unusually pale or washed out.

• Sudden, severe fatigue: If you feel extremely weak or dizzy, it could signal a dangerously low blood cell count.
• Unexplained or frequent infections: Repeated infections that don’t respond to treatment could mean your immune system is compromised.
• Uncontrolled bleeding: Excessive or prolonged bleeding, especially from small injuries, may indicate a dangerously low platelet count.

• Blood tests: A complete blood count (CBC) is used to measure the levels of red blood cells, white blood cells, and platelets. Abnormal results can suggest MDS.
• Bone marrow biopsy: A small sample of bone marrow is taken and examined under a microscope to check for abnormal cells. This is one of the most definitive tests for MDS.
• Genetic testing: Genetic tests may be done on bone marrow cells to look for mutations or changes in chromosomes that are common in MDS.

• Medications: Several medications are used to manage Myelodysplastic Syndrome by improving blood cell production and controlling abnormal cells. Growth factors are drugs that help stimulate the bone marrow to produce more blood cells. In cases where the immune system attacks the bone marrow, immunosuppressive drugs are used to suppress that immune response. Additionally, low-dose chemotherapy may be employed to reduce the number of abnormal cells in the bone marrow, helping to manage the condition more effectively.
• Blood transfusions: If anemia or low platelet counts are severe, transfusions of red blood cells or platelets can help manage symptoms.
• Stem cell transplant: In some cases, a bone marrow or stem cell transplant may be recommended. This can replace damaged bone marrow with healthy cells from a donor, but it's typically only considered for younger, healthier patients due to the risks involved.

• Persistent fatigue: Ongoing tiredness or weakness that doesn’t improve with rest could be a sign of low red blood cell levels.
• Frequent infections: If you’re experiencing repeated infections that don’t seem to respond to treatment, it may indicate a weakened immune system.
• Unexplained bruising or excessive bleeding: If you notice easy bruising, nosebleeds, or prolonged bleeding from minor cuts, this could signal low platelet counts and should be evaluated by a doctor.

• Avoid harmful chemical exposure: Limiting exposure to toxic chemicals like benzene and heavy metals, which can damage bone marrow, can reduce the risk of developing MDS.
• Quit smoking: Smoking can increase the risk of MDS and other blood-related disorders, so quitting can lower your overall risk.
• Monitor after cancer treatments: If you've undergone chemotherapy or radiation therapy, regular check-ups with your doctor can help detect MDS early.

• Healthy diet and lifestyle: A balanced diet rich in antioxidants can help support bone marrow health. Staying physically active also supports overall well-being.
• Regular blood tests: If you are at risk, especially after cancer treatments, regular blood tests can help catch early signs of MDS, allowing for early intervention.
• Consult your doctor: If you have a family history of MDS or other blood disorders, talk to your healthcare provider about monitoring and preventive steps.