Uterine Sarcoma

Uterine sarcoma is a rare type of cancer that forms in the muscle and supporting tissues of the uterus, known as the sarcomas. It is distinct from the more common cancer of the uterus, known as endometrial cancer, which starts in the lining of the uterus.

Dr. Chase on the Presentation of Uterine Sarcomas

Uterine sarcoma can develop in various parts of the uterus, including the smooth muscle (leiomyosarcoma), connective tissue (endometrial stromal sarcoma), and blood vessels (undifferentiated sarcoma).

While the exact cause of uterine sarcoma remains unknown, certain risk factors have been identified, such as previous radiation therapy to the pelvic area, history of certain genetic conditions, and age (most commonly diagnosed in women over 50 years old).

  • Abnormal vaginal bleeding, particularly after menopause
  • Pelvic pain or discomfort
  • Enlargement of the uterus
  • Feeling of fullness in the abdomen
  • Unexplained weight loss

Treatment for uterine sarcoma typically involves a combination of surgery, radiation therapy, and sometimes chemotherapy. The specific treatment plan depends on various factors like the type and stage of the sarcoma, overall health of the patient, and their preferences.

Surgery is often the primary treatment approach and may involve removing the uterus (hysterectomy) and nearby tissues, such as the ovaries and fallopian tubes. In more advanced cases, additional surgery may be needed to remove nearby lymph nodes or other affected organs.

Radiation therapy uses high-energy beams to target and destroy cancer cells. It can be administered before surgery to shrink the tumor, or after surgery to eliminate any remaining cancer cells. Chemotherapy, which involves powerful drugs, may be recommended in cases where the disease has spread beyond the uterus or recurred.

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Since the exact cause of uterine sarcoma is unknown, there are no specific prevention strategies for the disease. However, regular check-ups, awareness of the symptoms, and early diagnosis can greatly aid in the effective treatment and management of uterine sarcoma.

Uterine Sarcoma

  • Abnormal vaginal bleeding
  • Pelvic pain or discomfort
  • Feeling of heaviness in the pelvis
  • Abdominal pain or swelling
  • Pain during intercourse
  • Unexplained weight loss
  • Frequent urination
  • Bloating or a feeling of fullness

Uterine Sarcoma

Causes of Uterine Sarcoma

  • Genetic factors
  • Exposure to certain chemicals or toxins
  • Prior radiation therapy to the pelvic area
  • Hormonal imbalances
  • Abnormal growth of cells in the uterus
  • Age (more common in postmenopausal women)

Uterine Sarcoma Diagnosis

Medical History and Physical Examination:

A doctor will begin the diagnostic process by taking a detailed medical history, including information about symptoms experienced and any relevant family medical background. A physical examination will also be conducted to assess general health and examine the pelvic area for abnormalities.

Pelvic Ultrasound:

This non-invasive imaging technique uses high-frequency sound waves to create images of the uterus and surrounding structures. It can help identify the presence of tumors or abnormalities in the uterus.

Magnetic Resonance Imaging (MRI):

MRI uses a magnetic field and radio waves to produce detailed images of the uterus and nearby tissues. It provides more precise information about the size, location, and extent of the tumor.


A biopsy is the definitive method for diagnosing uterine sarcoma. It involves taking a small sample of tissue from the uterus for laboratory analysis. There are different types of biopsies, including:

  • Endometrial Biopsy: A thin tube is inserted through the cervix to obtain a sample of the endometrial lining.
  • Colposcopy-Guided Biopsy: A colposcope (a lighted magnifying instrument) is used to guide the biopsy instrument and obtain tissue samples from suspicious areas of the cervix or vagina.
  • Operative Hysteroscopy: A thin, lighted tube is inserted through the cervix to visualize and remove abnormal tissue from the uterus.

CT Scan (Computed Tomography):

In some cases, a CT scan may be ordered to evaluate the spread of uterine sarcoma to nearby lymph nodes or distant organs. It provides detailed cross-sectional images to aid in staging the disease.

Positron Emission Tomography (PET) Scan:

A PET scan may be used to identify potential metastasis by tracking the uptake of a radioactive substance injected into the body. It helps detect cancer in other parts of the body.

Blood Tests:

While there is no specific blood test to diagnose uterine sarcoma, certain blood markers may be elevated in some cases. Blood tests can assess the overall functioning of organs and detect any abnormalities.

It is important to note that the diagnostic process may vary depending on individual circumstances and the preference of the healthcare provider. Seeking professional medical advice and consultation is crucial for accurate diagnosis and appropriate treatment.