Waldenström’s macroglobulinemia (secondary infections)

Waldenström's Macroglobulinemia (Secondary Infections)

Waldenström's macroglobulinemia is a rare form of cancer that affects plasma cells in the bone marrow. Plasma cells are a type of white blood cell responsible for producing antibodies to help the body fight against infections.

In individuals with Waldenström's macroglobulinemia, abnormal plasma cells produce excessive amounts of a protein called macroglobulin, which can lead to thickening of the blood and impair the normal functioning of various organs.

One of the consequences of this condition is an increased susceptibility to secondary infections. The underlying immune system abnormalities make individuals more prone to contracting bacterial, viral, or fungal infections. These infections can affect different areas of the body, such as the respiratory system, urinary tract, skin, or gastrointestinal tract.

Treating secondary infections in individuals with Waldenström's macroglobulinemia requires careful management. It often involves a combination of targeted antimicrobial therapy, immunization against preventable infections, and vigilant monitoring of symptoms.

It is crucial that patients with this condition work closely with their healthcare providers to promptly identify and treat any secondary infections to minimize further complications and maintain overall health and well-being.

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Waldenström's macroglobulinemia (secondary infections)

  • Genetic mutations in the MYD88 or CXCR4 genes
  • Abnormal production of B lymphocytes
  • Overproduction of an abnormal protein called IgM
  • Buildup of IgM in the blood and bone marrow
  • Suppression of normal antibody production
  • Impaired immune system function

Waldenström's Macroglobulinemia (Secondary Infections)

  • Fever and chills
  • Recurrent infections
  • Weakness and fatigue
  • Weight loss
  • Enlarged lymph nodes
  • Night sweats
  • Easy bruising and bleeding
  • Shortness of breath
  • Swollen liver or spleen
  • Bone pain