Erwinase 10,000 Unit Solution For Injection Asparaginase Enzyme Therapy Agents

Erwinase 10,000 Unit Solution For Injection Asparaginase Enzyme Therapy Agents
Erwinase is a solution for injection that contains asparaginase enzyme. It is used as a therapy agent in the treatment of acute lymphoblastic leukemia (ALL) in patients who have developed an allergy to E. coli-derived asparaginase.
Active Ingredient: Erwinase 10,000 Unit Solution For Injection Asparaginase Enzyme Therapy Agents
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Side Effects

Pain or swelling at the injection site, nausea, vomiting, loss of appetite, headache, or tiredness may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: stomach/abdominal pain, pain/redness/swelling of arms or legs, muscle/joint pain, yellowing eyes/skin, dark urine, unusual bleeding/bruising (such as nose bleeds, black or bloody stools), signs of high blood sugar (such as increased thirst, frequent urination).

Get medical help right away if you have any very serious side effects, including: vision changes, severe headache, severe dizziness, seizures, chest pain.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Erwinia asparaginase is used to treat acute lymphoblastic leukemia (ALL). It works by starving tumor cells of needed nutrients and slowing tumor cell growth.

How to use Erwinase 10,000 Unit Solution For Injection Asparaginase Enzyme Therapy Agents

This medication may be given by injection into a muscle as directed by your doctor. The injection is given by a health care professional. Some brands may also be given by injection under the skin or into a vein by a health care professional, usually in a hospital setting. The dosage and treatment schedule are based on your medical condition and response to treatment.

Your doctor may give you other medication(s) to help prevent allergic reactions.


Before receiving this product, tell your doctor or pharmacist if you are allergic to it; or to any erwinia asparaginase products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: pancreatitis, liver disease.

Tell your health care professional that you are using erwinia asparaginase before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using this medication. Erwinia asparaginase may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Men and women using this medication should ask about reliable forms of birth control during treatment and for 3 months after the last dose. If you or your partner becomes pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 3 months after the last dose is not recommended. Consult your doctor before breast-feeding.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

This product may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
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    If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

    Lab and/or medical tests (such as complete blood counts, liver function, amylase levels, blood sugar) should be done while you are using this medication. Keep all medical and lab appointments.

    It is important to get each dose of erwinia asparaginase as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.

    Not applicable. This medication is given in a hospital or clinic and will not be stored at home.

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