Generic Priligy (Dapoxetine)

Priligy
Priligy
Priligy (Dapoxetine) is a novel medication specifically designed for the treatment of premature ejaculation in adult men. Priligy is designed for short-term use before sexual activity. Priligy offers a significant improvement in the control over ejaculation.
Active Ingredient: Dapoxetine
Dosage Form: Tablet
Dosage: 30 mg; 60 mg; 90 mg
Minimum Market Price: 0.45

Description

Priligy, known generically as Dapoxetine, is a selective serotonin reuptake inhibitor (SSRI) used primarily for the treatment of premature ejaculation in adult males. It is available in forms such as Priligy 30mg tablets and Priligy 60 mg tablets. It is recognized for its rapid onset of action and unique property as an as-required treatment, distinguishing it from other therapies in its class.

Pharmacological Profile

  • Class: Priligy belongs to the class of selective serotonin reuptake inhibitors (SSRIs). While SSRIs are commonly used as antidepressants, Priligy is used specifically for PE due to its unique pharmacokinetic properties.
  • Mechanism of Action: Dapoxetine works by inhibiting the serotonin transporter, leading to increased serotonin's action at pre- and postsynaptic receptors. Enhanced serotonin activity plays a key role in delaying ejaculation.

Drug Development and Efficacy

  • Development: The development of Priligy was focused on creating a fast-acting SSRI, suitable for on-demand use rather than continuous treatment.
  • Efficacy: Clinical trials have demonstrated that Priligy can significantly increase intravaginal ejaculatory latency time (IELT), improving control over ejaculation and reducing distress related to PE.

The pharmacological efficacy of Priligy (Dapoxetine) is characterized by several notable advantages in the therapeutic management of premature ejaculation:

  • Efficacy in Delaying Ejaculation: Clinical evidence supports the efficacy of Priligy in substantially delaying the occurrence of ejaculation, thereby mitigating the symptoms of premature ejaculation.
  • Prophylactic Use: It is suggested to consider Priligy for prophylactic use in individuals predisposed to premature ejaculation, to proactively manage this condition.
  • Extended Duration of Sexual Intercourse: Clinical trials have demonstrated that the use of Priligy can significantly extend the duration of sexual intercourse, often by threefold or more, enhancing sexual satisfaction.

General Instructions

Priligy should be consumed orally 1-3 hours before anticipated sexual activity, with the recommended starting dose being 30mg. It can be increased to Priligy 60 mg based on individual response and tolerability. It is available as Priligy 30mg and Priligy 60mg doses. Patients should start with the lower dose and can adjust based on their response and tolerance. It's not intended for continuous daily use.

Side effects

Common side effects of Priligy include nausea, headache, dizziness, and diarrhea. Most side effects are mild to moderate and transient. However, patients should be aware of the potential for fainting and should sit or lie down if they feel lightheaded or dizzy. However, severe side effects like fainting should be immediately reported to a healthcare provider.

Uses

Priligy is used for the treatment of premature ejaculation in men aged 18-64 years. The mechanism of action of Priligy involves its active ingredient dapoxetine, which acts upon specific serotonin receptors in the brain. This action modulates the neural pathways responsible for ejaculation. Its effectiveness lies in increasing the time to ejaculation and improving control over ejaculation, leading to a delay in ejaculation onset and a consequent increase in the duration of sexual intercourse.

Distinctively, Priligy demonstrates a rapid onset of action post-administration, distinguishing it from other similar medications which may take up to two weeks to manifest therapeutic effects.

Concerns

Patients with a history of cardiac conditions should use Priligy with caution. Those with a history of fainting or patients taking certain medications may be at increased risk of side effects. It's important to discuss your full medical history with a healthcare provider before starting Priligy dapoxetine.

What is Priligy?

Priligy is a medication used to treat premature ejaculation (PE) in men. It contains the active ingredient dapoxetine, which is a short-acting selective serotonin reuptake inhibitor (SSRI).

How does Priligy work?

Priligy works by increasing the activity of serotonin in the nervous system. Serotonin is a neurotransmitter that is involved in passing messages between nerve cells. It has various functions, including regulating the ejaculation process.

Who can use Priligy?

Priligy is prescribed for adult men aged 18 to 64 who have all of the following: a history of premature ejaculation, poor control over ejaculation, and a marked personal distress or interpersonal difficulty as a result of PE.

What is the recommended dosage of Priligy?

The recommended starting dose of Priligy is 30 mg, taken 1 to 3 hours before sexual activity. If the effect is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg.

What are the side effects of Priligy?

Common side effects of Priligy include dizziness, headache, nausea, diarrhea, insomnia, and fatigue. These side effects are usually mild to moderate in intensity and temporary.

How quickly does Priligy take effect?

Priligy is usually taken 1 to 3 hours before sexual activity. It can work quickly, often within 1 hour, but its effectiveness may vary from person to person.

Can Priligy be taken with alcohol?

Alcohol should not be consumed when taking Priligy as it can increase the risk of fainting and other side effects. It may also increase the risk of injury from fainting.

Is a prescription required for Priligy?

Yes, Priligy is a prescription medication. It's important to consult with a healthcare provider to ensure it's safe and suitable for you to use.

Can Priligy cure premature ejaculation permanently?

Priligy is not a cure for premature ejaculation but a treatment to manage the condition. It helps to prolong the time taken to ejaculate and can improve control over ejaculation.

Can Priligy be taken with other medications?

Priligy can interact with certain medications, so it's important to inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements.

When not to use?

Priligy is contraindicated in patients with hypersensitivity to dapoxetine HCL or any other component of the formulation. It should not be used in conjunction with recreational drugs or alcohol. It's also advised against in individuals with significant psychiatric or cardiac conditions.

Warnings

Priligy can cause orthostatic hypotension. Patients should be warned about the possibility of syncope and other side effects such as visual disturbances. Priligy should be used with caution in patients with mild or moderate renal impairment and is not recommended for those with severe renal impairment.

Dosage

The recommended starting dose is Priligy 30mg, taken as needed approximately 1 to 3 hours prior to sexual activity. Depending on individual efficacy and tolerability, the dose may be increased to 60 mg. The maximum recommended dosing frequency is once every 24 hours.

Interactions

Priligy should not be used with monoamine oxidase inhibitors or serotonin reuptake inhibitors, as it may increase the risk of serotonin syndrome. Caution is advised when taken with medications affecting hepatic metabolism.

Other details

Clinical trials have shown that Priligy, combined with behavioral therapy and psychological counseling, may further enhance its effectiveness. Patients are advised to discuss with their healthcare provider for personalized advice.

References

  1. Chaplin, S., & Mostyn, P. (2014). Dapoxetine: licensed treatment for premature ejaculation. Prescriber, 25. Link
  2. Cai, D., et al. (2020). [Priligy combined with behavioral therapy and psychological counseling for primary premature ejaculation]. Zhonghua nan ke xue = National journal of andrology, 26(7), 611-615. Link
  3. Kowey, P., et al. (2011). Cardiovascular Safety Profile of Dapoxetine during the Premarketing Evaluation. Drugs in R&D, 11, 1 – 11. Link
  4. Modi, N., et al. (2006). Single‐ and Multiple‐Dose Pharmacokinetics of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation. The Journal of Clinical Pharmacology, 46.
  5. Qoctor. 2021. Premature Ejaculation Patient Information Leaflet. Link
  6. Mirone, V., et al. (2014). Results from a prospective observational study of men with premature ejaculation treated with dapoxetine or alternative care: the PAUSE study. European urology, 65(4), 733-9. Link
  7. Medicines.org.uk. 2021. Priligy 30 mg film-coated tablets – Summary of Product Characteristics (SmPC) – (emc). Link
Respond: 4
Rating:
(5)
  1. I am a bit worried about side effects, exactly about apathy or depression as I have this syndrome without any side effects.. Should I try this drug in my case?

    • You’re welcome! I’m glad to hear that the article on Generic Priligy was helpful to you. If you have any more questions or need further information, feel free to ask.

Minimum Market Price
$0.45