Many men in different periods of their life can face such an unpleasant phenomenon as weakness of erection. The scientific name of this disease sounds like “erectile dysfunction”.
ED makes an intimacy life impossible or seriously complicates sexual intercourse. Fortunately, with the help of a medicine named Nizagara it is possible to cope with this problem quickly enough.
General description of the medical product
The revolutionary medicine Nizagara has already got millions of fans all over the world. This medicament is interesting for it includes not only the active substance but also vitamins.
The main factor of Nizagara is Sildenafil. This agent successfully fights against male erectile dysfunction and allows a man to enjoy sex. Those vitamins strengthen the body and the reproductive system as a whole.
Initially, active substance was synthesized in order to improve blood circulation in the myocardium and to treat angor pectoris and coronary heart disease.
However, in 1992 during the clinical investigations it was discovered that the active substance influence on the cardiac blood circulation is minimal. For instance, it has a pronounced effect on the blood flow in the pelvic organs including the penis.
Besides active substance Nizagara contains vitamins, such as:
- L-arginine. It reduces the risk of cardiovascular disease, improves blood circulation, increases the spermiation and creates conditions for a longer erection.
- Redberry. It has a revitalizing effect, increases immunity and vascular tone.
- Adermin (Vitamin B6). It improves protein production, hepatic function, increases endurance at various types of loads on a human body, promotes the growth of muscle tissue.
- Vitamin B12. In combination with folic acid it has a positive effect on the function of hematopoiesis and on the nervous system, as well as increases the possibility of skin regeneration.
- Folic acid reduces the risk of cardiovascular disease (in particular myocardial infarction and stroke), helps to normalize cholesterol and blood pressure. It produces a positive impact on encephalon and improves its efficiency.
- Folic acid. It is involved in metabolic processes, reduces stress, increases the count of spermatozoa and helps to keep man's health in great shape.
Drug form and storage
Nizagara is a tablet of blue color and oblong or round form. It is for sale in blisters for 10 pcs. Each pill contains 25 mg, 50 mg or 100 mg of active substance (it is depending on the dosage). Tablets should be stored in a dry ventilated room protected from pets, children, moisture, heat sources and sun rays. The temperature in the storage place should not exceed 25 °C.
The drug increases the amount of incoming blood to the penis. It helps a man to achieve a natural erection. Sildenafil only acts when a man experiences natural sexual excitement, and when the sexual congress is finished the penis naturally returns to a relaxed state. The substance only acts via natural mechanisms of erection. It does not help to feel any sexual vigor.
The efficacy of a medicine
Let's focus on the experiments held in the USA at 37 medical centers. They were attended by 828 men whose average age was 54 years.
A number of conditions were present in all those human subjects:
- presence of erectile dysfunction for the last 6 months;
- sexual activity within the same period with one woman only;
- absence of anatomical curvature of penis, also peptic ulcer, diabetes, mental disorders. Besides that, apoplectic attack or heart attack for the last 6 months
The experiment lasted 25 weeks.
People who received the medicine in a dosage of 25, 50 and 100 mg had their ability to erect increased by 60, 84, 100%, respectively.
The study showed that the effectiveness of the medicine is high to improve the men sexual vigor and a successful sexual intercourse. However, sometimes the medicine can’t help to resolve the problem. Often this is due to improper usage of the medicine.
Dosing and Administration
Time of taking the medicine should be the same as of the commonly used Viagra (30 minutes before the sexual intercourse). The usual dose is one tablet or 25 mg of the active substance. If you have a higher dosage, just divide it into several parts.
The effect of the product, as a rule, lasts for five hours. If the effect is insufficient the dosage can be increased to two tablets per day.
Bioavailability of the medicine is 25-60%. When you get the product with fatty foods its action slows down to 1.5 – 3 hours.
For better efficiency take the pill on an empty stomach. In addition, sex drive is important. Therefore, this product does not affect the libido itself, so it only helps to create an erection.
You may use Nizagara occasionally (if necessary) or in a common treatment complex, as a combination therapy of impotence or erectile dysfunction.
Contraindications and side effects
Studies showed high safety of medical preparation. There were no abnormalities with the state of health in men from 19 to 85 years old, while taking the drug. Above all, you will not get any addiction to this medicine.
On-treatment adverse event were observed only in men who had risk factors for cardiovascular complications and suffered from diabetes mellitus or visual impairment.
Side effects are usually easily remedied. Age does not have a clinically significant effect on the incidence of side effects. Therefore, dosage adjustment for the elderly is not required.
Some side effects develop quite often. For example, taking tablets many men experience blood flushes to the face, dizziness, migraine. Besides, the other common side effects are blurred vision, changes in photosensitivity, also nasal congestion, and visual impairment (they are reversible).
There are other side effects as well:
- Firstly, rare – distortion of the structure and function of the conjunctiva of the eye, rapid heartbeat, not normal blood pressure, tachycardia, nausea, dry mouth, chest pain, weakness, priapism, muscle pain, vomiting, tinnitus.
- Secondly, very rare – cerebrovascular disorders, reversible deafness, blood pressure jumps, nosebleeds, muscle cramps, redness of the eyes, anaphylactic and allergic reactions.
- Thirdly, with longer therapies the following is possible – distortion of the field of vision, vasoconstriction of amphiblestrodes, unstable angor pectoris. Besides, such as schemic attack, ischemic optic neuropathy of non-arterial genesis, insomnia, hemorrhage in the amphiblestrodes.
This medicine is not for women use or men under 18 years. People who suffer from at least one of the following diseases also cannot use this drug:
- Hypersensitivity to active substance or any other components of the medicinal product;
- Acute cardiac distress;
- Serious kidney diseases;
- Thyroid disorders;
- Acute trauma of the spine;
- Severe atherosclerosis.
- Anatomical deformations of the penis,
- Crescent cell anemia,
- Multiple myeloma,
If the patients have various cardiovascular diseases they should consult a doctor in advance.
Do not apply the medicament if you apply continuously or intermittently donators of nitric oxide, organic nitrates or nitrites in any other forms.
Doctors do not recommend simultaneous use of the drug with Ritonavir. When you combine it with Ritonavir, the maximum single dose of active substance should be 25 mg and the dosing frequency of medicine should be once every 48 hours.
How Nizagara works?
Active substance (Sildenafil) inhibits an enzyme called Phosphodiesterase type-5. As a result it creases blood flow in the penis with simultaneous relaxation of muscle.
- The highest dose of Sildenafil is 100 mg per day.
- In case of an overdose, the likelihood of side effects increases dramatically.
- In addition, extremely high a dose of any medicine can be threatening to life and health.