Generic Ponstel (Mefenamic acid)

Generic Ponstel
Ponstel (Mefenamic Acid) is a medicine used against such health conditions as acute rheumatism, non-specific (rheumatoid) polyarthritis, ankylosing spondylitis, arthralgia, myalgia, neuralgia, headache, toothache, fever, and some others. The correct diagnosis, as well as dosage, should be prescribed only by attending physician.
Active Ingredient: Mefenamic Acid
Dosage Form: Tablet
Dosage: 250 mg Tablet; 500 mg Tablet;
Minimum Market Price: $0.12

General information

Pain is a natural reaction of the body to any pathological processes occurring in it. It is not necessary to suffer from pain. Therefore, along with the prescribed treatment courses, doctors often prescribe painkillers, which simultaneously relieve inflammatory processes. Such agents belong to the NSAIDs (nonsteroidal anti-inflammatory drugs) group. Non-steroid – means non-hormonal.

Generic ponstel (Mefenamic acid) is eactly the agent of this non-steroidal anti-inflammatory group. The mechanism of action is aimed at the suppression of the inflammatory mediators’ synthesis, reduce vascular permeability, and affect the activity of biocatalysts involved in the inflammatory response. It helps to enhance cell resistance, stimulate wound healing and the formation of interferon. It has not only anti-inflammatory action, but also febrifuge as well as analgesic properties.

Due to the pronounced febrifuge, pain-killing and anti-inflammatory effects, it is successfully used in many pathological conditions. Special immunostimulating features and a favorable safety profile make it the medication of choice for ARVI treatment.

The antipyretic properties of Mefenamic acid are associated with its inhibiting ability aimed at the prostaglandins synthesis and in parallel affect the thermoregulation center in the human’s brain.

Immunomodulatory properties of the discussed medication have been widely studied starting from the 1980s and are being studied to date. Unlike most other NSAIDs, this medication stimulates the production of interferon – an antiviral factor of a protein nature. In addition, this agent helps to enhance the functional activity of T-lymphocytes, including the normalization of the ratio of CD4 cells (T-helpers) and CD8 (T-suppressors).

This pharmaceutical product is prescribed in case of such conditions as acute rheumatism, nonspecific infectious polyarthritis, ankylosing spondylitis, arthralgia, myalgia, neuralgia, headache, toothache, fever, infectious-allergic myocarditis, dysmenorrhea, premenstrual syndrome, colds as well as fevers, flu, periodontal diseases. In addition, Generic ponstel is presribed for the purpose of amelioration of menstrual pains.

Moreover, it is believed that the discussed agent can cure Alzheimer's disease.


Generic ponstel, which is useful for different age categories, has of course some contraindications, which include such conditions as hypersensitivity to the components included into the drug. In addition, the medication should never be administered in case of the past history of such diagnoses as bronchial spasm, Quincke's oedema, rhinitis, bronchial asthma or nettle-rash that occurred after using acetylsalicylic acid or other NSAIDs. The simultaneous intake of specific inhibitors of COX-2 should also be avoided. The medciation should never be used in case of diagnosed gastric ulcer and duodenal ulcer, including inflammatory bowel disease in anamnesis, diseases of the blood-forming organs, severe heart insufficiency, severe liver or kidneys disorders, gastroenterorrhagia or tresis caused by taking the discussed medication.

With great caution this drug should be given to patients diagnosed with acute cardiovascular insufficiency, hypertension, coronary heart disease. Also it has to be recommended with great caution to individuals suffering from epilepsy.

Those individuals who are diagnosed with exanthematous lupus erythematosus and mixed CTD are under a serious risk of viral meningitis development.

Use of this product may result in impaired female capability of reproduction and is not advised to those women who are trying to get pregnant as this may prevent the pregnancy. In case of lack of a therapeutic effect when used against dysmenorrhea and menorrhagia it is necessary to consult a doctor.

The treatment is restricted to be used in children under 5 years, and in pregnant and lactating females.

Furthermore, care should be taken when driving vehicles or working with mechanisms requiring increased attention, as sometimes use of a agent can cause drowsiness, blurred vision, and convulsions.

Mefenamic Acid Dosage

The impact of any medicine will be more effective if you use it according to the instructions or recommendations given by the attending physician. This medication dosage depends on the individual’s age. There are two tablets forms – 250 mg and 500 mg. Adults and children over 12 years old are prescribed 250-500mg 3-4 times a day. If there are no side effects, and there is a need, it can be increased to 3000 mg or 6 tablets of 500 mg. In case of visible improvements, the dosage is reduced to 1000 mg. Children from 5 to 12 years old are supposed to take a dosage of 250 mg 3-4 times a day.

However, it should be remembered that this medication, as well all other, should be used under the supervision of a physician, who determines the amount, schedule and duration of treatment.

How to take Mefenamic Acid?

It is important to know that, there is a specific rule to use this agent, i.e. it has to be taken in the correct way. This is because it, like most drugs, has its own characteristics. The use of Mefenamic acid is allowed only after a meal in order to minimize the possible negative effects on the digestive organs. The second important condition is that this medication should be washed down not with water, but with milk. This applies to precautions – the stomach, especially in children and sensitive people, is better tolerated to treatment. If the patient does not drink milk or has an intolerance to this product, then you can replace it with water.

Mefenamic acid for children of 5-10 years old is prescribed in a single dose of 250 mg, and for children over 10 years old – 300 mg, the doses rate for these age groups is 3-4 times a day.

Usually the course of treatment with this product amounts to 20-45 days, but if necessary, it can be extended up to 2 months or more.
Mefenamic acid can be used topically in the form of a 1% paste or a 0.1-0.2% solution. Paste is recommended to apply into the periodontal pockets in 1-2 days (6-8 sessions), and using an aqueous solution should be applied 1-2 times a day for ulcerative lesions of the oral mucosa.

Mefenamic Acid Side-effects

In addition to contraindications, this highly effective medication has some side reactions. Before using the pills, you should familiarize with this list in order to be fully prepared, especially if the medicine is taken for the first time:

  • indigestion – bloating, nausea, belching;
  • ache in the pit of the stomach;
  • indigestion;
  • high pressure, edema, tachycardia, arrhythmia;
  • bronchospasm as well as shortness of breath;
  • anemia, and other abnormalities in the blood picture;
  • kidney inflammation, hematuria, disorders of the urinary system;
  • sleep disturbance and irritation;
  • all sorts of skin eruptions, including urticaria.


In case of exceeding the specified dosage, there can be manifestation of such symptoms as:

  • pain in epigastric region, sickness, vomiting as well as drowsiness.
  • In severe cases there can be manifestations of gastrointestinal bleeding, respiratory depression, hypertension, twitching of certain muscle groups, and even coma.

Until now there is no any specific antidote. It is recommended to perform gastric lavage using activated carbon suspension. Also it can be performed alkalinization of urine and forced diuresis. As in every other case of overdose it is recommended to perform symptomatic therapy. Hemosorption and hemodialysis are ineffective due of the ability of Mefenamic acid to bind with the blood proteins.


Such NSAIDs as salicylates and metamizole sodium increase the antiphlogistic action. Thiamine, pyridoxine, barbiturates, phenothiazine derivatives, narcotic analgesics, caffeine, phenacetin, diphenhydramine potentiate analgesia. Mefenamic acid prolongs prothrombin period and increases the oral anticoagulants effectiveness. In addition, it is known that myelotoxic agents increase the discussed agnet hematotoxicity manifestations.

In case of simultaneous administration of this pill and methotrexate, the toxic effect of the latter is enhanced. When this agent is simultaneously used with warfarin there is a risk of gastrointestinal bleeding.

Painkillers, to which Generic ponstel belongs, are not recommended to be combined with each other. Taking two or three analgesics at the same time will not enhance the analgesic effect, but will dramatically increase the risk of stomach ulcer development, including even ulcerative bleeding.

It should be stated that care must be taken when using Generic ponstel in individuals treating with drugs which can enhance the bleeding risk, namely corticosteroids, anticoagulants and aspirin.

Alcohol interaction

  • There is not a single medicine that doctors would advise to use with alcohol.
  • Given the fact that using nonsteroidal anti-inflammatory agents, which include Generic ponstel, quite often can result in gastrointestinal tract disruptions, in particular to gastric ulcer and duodenal ulcer, combining them with alcohol is strictly restricted.
  • Ethanol in the composition of alcoholic beverages burns and erodes the mucous membrane of the gaster – and this is well-known fact. It is also well-known that nonsteroidal anti-inflammatory drugs inhibit the production of protective mucus. Their combination greatly increases the gastrointestinal bleeding risk. Erosion or even ulcer in this case develops in each person, and the risk of internal bleeding is observed in 50-70% of cases.
  • Moreover, various groups of NSAIDs, reacting with alcohol, can result in other health disorders.

Mefenamic Acid Reviews

Sally: I have been using Generic ponstel, containing Mefenamic acid, when I had fevers. This medication works very well if you take it as soon as the first signs of flu appear, namely, cracking, malaise and headache.

Dorothy: When my child (9 years old) had a fever above 38, the doctor suggested giving him Generic ponstel (Mefenamic acid). The drug acted in 15-20 minutes. The child felt relieved and fell asleep. Now I always have this drug in my first-aid kit.

Sabina: Sometimes ago my husband got radicular pain. He could not move because of severe pain. We were recommended to use this product and we liked the result.

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