What drugs can cause erectile dysfunction?

The cause of erectile dysfunction in 25% of cases is medications taken by a man. pharmacoepidemiological researches confirm these observations.


Antipsychotic medicines cause erectile dysfunction due to the inhibitory effect on the dopaminergic and cholinergic system. This side effect is most often observed during the use of medicines containing phenothiazine (derivatives of thioxanthene and butyrophenone). It is necessary to use other drugs that do not have such side effects (atypical antipsychotics) if impotence has developed during antipsychotic therapy. The patient can take drugs that suppress side effects (sildenafil, bromocriptine, carboline).


Erectile dysfunction in men with depression may occur as a result of this disease. However, there are often cases when erectile dysfunction is a side effect of the medications taken. Antidepressant drugs can suppress sexual function in the central nervous system, brain regions responsible for the perception of sexual reactions. Erection disorders occur most often if the patient is taking selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants.

A man needs to see a doctor if he has problems with potency. In this case, the doctor may reduce the dose of the drug, use intermittent therapy or prescribe drugs that reduce the severity of erectile dysfunction (such as sildenafil, tadalafil, vardenafil, kamagra, suhagra, tadacip, revatio, cenforce).
Antiepileptic drugs

Erectile disorders cause most often such antiepileptic drugs as phenytoin, phenobarbital, gabapentin, carbamazepine, clonazepam and primidone.

Medicines for the treatment of diseases of the cardiovascular system

  • Erectile dysfunction occurs in men with arterial hypertension. This dysfunction is a side effect of antihypertensive drugs (belonging to different therapeutic groups) and diuretics (mainly thiazide drugs).
  • Such antihypertensive drugs as beta-blockers and, above all, propanolol, most often lead to erectile dysfunction. In this case, the safest medicines are bisoprolol and betaxolol. The risk of impotence when they are taken is almost zero.
  • Erection problems are also observed if patients are taking antiarrhythmic medicines used in the treatment of cardiac rhythm disorder.

Urological drugs

Erectile dysfunction occurs in patients with urinary incontinence problems if they take drugs such as oxybutynin and tolterodine (anticholinergic drugs). The problem of impotence also occurs during hormone therapy for prostate cancer.

Drugs used in gastrointestinal disorders and diseases

  • Treatment of chronic diarrhea (which occurs in intestinal diseases) with medicines containing diphenoxylate often leads to erectile dysfunction.
  • A man can change the medicine to another if a side effect becomes too serious a problem for him. In this case, loperamide is a good drug of choice. It has an antidiarrheal effect but does not cause erectile dysfunction.
  • In addition, erectile disorders were noted during the treatment with antifungal agents (ketoconazole, itraconazole).

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  • Erectile Dysfunction
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    • It is the inability to achieve and maintain an erection sufficient to perform sexual intercourse. It is one of the most common sexual disorders in men.

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  • Men’s Health
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    • Men’s health is the basis not only of the family happiness but also of the welfare of the state and the community. It is very important to know what to do in order not to get weak in the intimate sphere and how to maintain the reproductive ability.

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